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外周白细胞介素-18 与抑郁症患者异常脑活动呈负相关：一项静息态 fMRI 研究。

Peripheral Interleukin-18 is negatively correlated with abnormal brain activity in patients with depression: a resting-state fMRI study.

机构信息

Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, 215004, China.

出版信息

BMC Psychiatry. 2022 Aug 5;22(1):531. doi: 10.1186/s12888-022-04176-8.

DOI:10.1186/s12888-022-04176-8
PMID:35931995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9354267/
Abstract

BACKGROUND

Interleukin-18 (IL-18) may participate in the development of major depressive disorder, but the specific mechanism remains unclear. This study aimed to explore whether IL-18 correlates with areas of the brain associated with depression.

METHODS

Using a case-control design, 68 subjects (34 patients and 34 healthy controls) underwent clinical assessment, blood sampling, and resting-state functional Magnetic Resonance Imaging (fMRI). The total Hamilton depression-17 (HAMD-17) score was used to assess depression severity. Enzyme-linked immunosorbent assay (ELISA) was used to detect IL-18 levels. Rest-state fMRI was conducted to explore spontaneous brain activity.

RESULTS

The level of IL-18 was higher in patients with depression in comparison with healthy controls. IL-18 was negatively correlated with degree centrality of the left posterior cingulate gyrus in the depression patient group, but no correlation was found in the healthy control group.

CONCLUSION

This study suggests the involvement of IL-18 in the pathophysiological mechanism for depression and interference with brain activity.

摘要

背景

白细胞介素-18（IL-18）可能参与了重度抑郁症的发展，但具体机制尚不清楚。本研究旨在探讨 IL-18 是否与与抑郁相关的大脑区域有关。

方法

采用病例对照设计，68 名受试者（34 名患者和 34 名健康对照者）进行临床评估、采血和静息态功能磁共振成像（fMRI）检查。采用汉密尔顿抑郁量表-17 项（HAMD-17）评估抑郁严重程度。酶联免疫吸附试验（ELISA）检测 IL-18 水平。静息态 fMRI 用于探索自发性脑活动。

结果

与健康对照组相比，抑郁症患者的 IL-18 水平更高。在抑郁症患者组中，IL-18 与左侧后扣带回脑区的度中心度呈负相关，但在健康对照组中未发现相关性。

结论

本研究提示 IL-18 参与了抑郁症的病理生理机制，并干扰了大脑活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/766f3435c3c7/12888_2022_4176_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/f3734f22089d/12888_2022_4176_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/3a6865d85814/12888_2022_4176_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/766f3435c3c7/12888_2022_4176_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/f3734f22089d/12888_2022_4176_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/3a6865d85814/12888_2022_4176_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7622/9354267/766f3435c3c7/12888_2022_4176_Fig3_HTML.jpg

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