酰胺质子转移加权磁共振成像预测脑膜瘤硬度的可行性研究
Amide Proton Transfer Weighted MR Imaging for Predicting Meningioma Stiffness: A Feasibility Study.
作者信息
Yu Hao, Zhu Laimin, Wang Yanting, Yue Xiuzheng, Wang Weiwei, Sun Zhanguo, Jiang Shanshan, Chen Yueqin, Wen Zhibo
机构信息
Department of Radiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Clinical Medical College of Jining Medical University, Jining, Shandong, China.
出版信息
J Magn Reson Imaging. 2023 Apr;57(4):1071-1078. doi: 10.1002/jmri.28379. Epub 2022 Aug 5.
BACKGROUND
Stiffness of meningioma is an important factor affecting the surgical resection and the prognosis of patients.
PURPOSE
To examine the feasibility of APTw-magnetic resonance imaging (MRI) in evaluating meningioma stiffness.
STUDY TYPE
Retrospective.
POPULATION
Seventy-one patient with meningiomas, 39 were male and 32 were female; the mean age was 51 ± 10 years.
FIELD STRENGTH/SEQUENCE: 3.0T; Turbo-spin-echo T -weighted and Gd-T -weighted sequence; Turbo-spin-echo T -weighted sequence; 2D fat-suppressed, turbo-spin-echo APTw pulse sequence.
ASSESSMENT
The T WI signal intensity score, T WI signal intensity score, APTw , APTw , and APTw values were compared between soft, medium stiff and stiff meningiomas or non-stiff meningiomas and stiff meningiomas group.
STATISTICAL TESTS
Chi-square test, one-way ANOVA analysis, independent-samples t-test, intra-class correlation coefficient, rank-sum test, receiver operating characteristic curve analysis. P < 0.05 was considered statistically significant in all tests.
RESULTS
APTw and APTw in the stiff group were significantly lower than that in the non-stiff group (2.79% ± 0.42% vs. 1.90% ± 0.60% and 3.20% ± 0.31% vs. 2.55% ± 0.61%). APTw and APTw in the stiff group were significantly lower than that in the medium stiff and soft groups (1.90% ± 0.60% vs. 2.69% ± 0.40% and 3.12% ± 0.32%, 2.55% ± 0.61% vs. 3.17% ± 0.33% and 3.39% ± 0.18%), APTw in the medium stiff group was significantly lower than in the soft group, there was no significant difference in APTw between the medium stiff and soft groups (P = 0.190). APTw showed the best diagnostic performance for evaluating meningioma stiffness with an area under the curve of 0.913, when the APTw was lower than 2.4%, the meningioma was defined as a stiff tumor, the sensitivity, specificity, and accuracy were 87.1%, 87.5%, and 85.9%, respectively.
DATA CONCLUSION
APTw-MRI could be used to evaluate meningioma stiffness, with APTw having the best evaluative efficiency.
LEVEL OF EVIDENCE
3 TECHNICAL EFFICACY: Stage 1.
背景
脑膜瘤的硬度是影响手术切除及患者预后的重要因素。
目的
探讨非对称相位对比加权磁共振成像（APTw-MRI）评估脑膜瘤硬度的可行性。
研究类型
回顾性研究。
研究对象
71例脑膜瘤患者，男性39例，女性32例；平均年龄51±10岁。
场强/序列：3.0T；快速自旋回波T加权和钆喷酸葡胺T加权序列；快速自旋回波T加权序列；二维脂肪抑制快速自旋回波APTw脉冲序列。
评估
比较软、中等硬度和硬脑膜瘤组或非硬脑膜瘤组与硬脑膜瘤组之间的T2WI信号强度评分、T1WI信号强度评分、APTw、APTw及APTw值。
统计分析
卡方检验、单因素方差分析、独立样本t检验、组内相关系数、秩和检验、受试者工作特征曲线分析。所有检验中P<0.05认为具有统计学意义。
结果
硬脑膜瘤组的APTw和APTw显著低于非硬脑膜瘤组（2.79%±0.42%对1.90%±0.60%以及3.20%±0.31%对2.55%±0.61%）。硬脑膜瘤组的APTw和APTw显著低于中等硬度和软脑膜瘤组（1.90%±0.60%对2.69%±0.40%以及3.12%±0.32%，2.55%±0.61%对3.17%±0.33%以及3.39%±0.18%），中等硬度组的APTw显著低于软脑膜瘤组，中等硬度和软脑膜瘤组之间的APTw无显著差异（P=0.190）。APTw在评估脑膜瘤硬度方面表现出最佳诊断性能，曲线下面积为0.913，当APTw低于2.4%时，将脑膜瘤定义为硬肿瘤，敏感性、特异性和准确性分别为87.1%、87.5%和85.9%。
数据结论
APTw-MRI可用于评估脑膜瘤硬度，其中APTw评估效率最佳。
证据水平
3级 技术效率：1级
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