Department of Pathology/Lab Medicine, All India Institute of Medical Science, Patna, India.
Diagn Cytopathol. 2022 Dec;50(12):E361-E366. doi: 10.1002/dc.25029. Epub 2022 Aug 6.
Ocular sebaceous carcinoma (OSC) is a malignant and potentially lethal sebaceous gland tumor. Clinically, it masquerades as other benign and less malignant lesions, resulting in a delay in diagnosis.
In the present study, we sought to evaluate the cytomorphology of this aggressive neoplasm diagnosed by fine-needle aspiration cytology (FNAC) last year at our institute.
RESULTS/FINDINGS: We report three cases of OSC diagnosed on aspiration cytology showed a cellular smear composed of sheets, 3D clusters, papillaroid, and singly scattered polygonal tumor cells having centrally located hyperchromatic pleomorphic nuclei and multiple microvacuolations in the cytoplasm. Necrosis and crushing artifact were also identified. Special stains such as Oil Red O stain on air-dried smears showed positivity, confirming the presence of lipid globules. Subsequently, the Cytological impression of sebaceous carcinoma was confirmed on histopathology.
The article highlights the role of FNAC in the early and correct diagnosis of aggressive tumors and subsequent appropriate management to prevent recurrence and metastasis.
眼附属器皮脂腺癌（OSC）是一种恶性且具有潜在致命性的皮脂腺肿瘤。临床上，它可能伪装成其他良性和恶性较低的病变，导致诊断延迟。
本研究旨在评估去年在我院通过细针抽吸细胞学（FNAC）诊断的这种侵袭性肿瘤的细胞形态学。
结果/发现：我们报告了三例 OSC 的病例，在抽吸细胞学检查中显示出由片状、3D 簇、乳头状和单个散在的多边形肿瘤细胞组成的细胞涂片，这些细胞具有中央位置的深染多形性核和细胞质中的多个微空泡。还发现了坏死和压碎伪影。空气干燥涂片上的特殊染色，如油红 O 染色，呈阳性，证实存在脂质小球。随后，组织病理学证实了皮脂腺癌的细胞学印象。
本文强调了 FNAC 在早期正确诊断侵袭性肿瘤以及随后进行适当管理以预防复发和转移方面的作用。
