State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China.
Cell Mol Life Sci. 2022 Aug 6;79(9):470. doi: 10.1007/s00018-022-04498-6.
Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded in the past decade. Gut microbiota changes may be a crucial regulatory component in systemic inflammatory arthritis. As a result of advancements in the field, microbiota-assisted therapy has evolved, but this discipline is still in its infancy. Consequently, we review the limitations of current systemic inflammatory arthritis treatment, analyze the connection between the microbiota and arthritis, and summarize the research progress of microbiota regulating systemic inflammatory arthritis and the further development aspects of microbiota-assisted therapy. Finally, the partial mechanisms of microbiota-assisted therapy of systemic inflammatory arthritis are being discussed. In general, this review summarizes the current progress, challenges, and prospects of microbiota-assisted therapy for systemic inflammatory arthritis and points out the direction for the development of microbiota-assisted therapy in the future.
过去十年，肠道微生物群对系统性炎症性关节炎的影响研究呈爆炸式增长。肠道微生物群的变化可能是系统性炎症性关节炎的一个关键调节组成部分。由于该领域的进步，微生物辅助治疗已经发展起来，但这一学科仍处于起步阶段。因此，我们回顾了目前系统性炎症性关节炎治疗的局限性，分析了微生物群与关节炎之间的联系，并总结了调节系统性炎症性关节炎的微生物群的研究进展和微生物辅助治疗的进一步发展方向。最后，讨论了微生物辅助治疗系统性炎症性关节炎的部分机制。总的来说，本综述总结了微生物辅助治疗系统性炎症性关节炎的当前进展、挑战和前景，并指出了未来微生物辅助治疗发展的方向。
