Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
Vet Res Commun. 2022 Dec;46(4):1195-1207. doi: 10.1007/s11259-022-09979-4. Epub 2022 Aug 6.
Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic disease with a high mortality rate for humans and cats. The clinical course and prognosis of SFTS in dogs remains unclear. In the present study, we investigated the clinical and epidemiological characteristics of SFTS virus (SFTSV) infection in dogs. All evaluated dogs exhibited an acute course and symptoms including fever (57.1%), anorexia (57.1%), depression (42.9%), and vomiting (35.7%). Thrombocytopenia was present in 45.5% of dogs, while jaundice was not observed. C-reactive protein, alanine transaminase, and alkaline phosphatase were elevated in some cases. Viral clearance occurred within 6 to 26 days. Phylogenetic analysis revealed that the SFTSV sequences were consistent with viruses circulating in the Republic of Korea. As dogs often live in close contact with humans, awareness of the clinical and epidemiological features of SFTS in dogs is crucial. Further large-scale studies are necessary to investigate SFTSV infection in dogs.
严重发热伴血小板减少综合征（SFTS）是人畜共患病，人类和猫的死亡率很高。狗的 SFTS 临床过程和预后尚不清楚。在本研究中，我们调查了狗 SFTS 病毒（SFTSV）感染的临床和流行病学特征。所有评估的狗均表现出急性病程和症状，包括发热（57.1%）、食欲不振（57.1%）、抑郁（42.9%）和呕吐（35.7%）。45.5%的狗存在血小板减少症，而无黄疸。一些病例中 C 反应蛋白、丙氨酸转氨酶和碱性磷酸酶升高。病毒清除发生在 6 至 26 天内。系统进化分析表明，SFTSV 序列与韩国流行的病毒一致。由于狗经常与人密切接触，因此了解狗的 SFTS 临床和流行病学特征至关重要。需要进一步开展大规模研究来调查狗 SFTSV 感染。
