生长激素在大鼠脂肪细胞从哺乳期恢复过程中脂肪分解适应性变化中的作用。
Role of growth hormone in the adaptations of lipolysis in rat adipocytes during recovery from lactation.
作者信息
Vernon R G, Finley E, Flint D J
出版信息
Biochem J. 1987 Mar 15;242(3):931-4. doi: 10.1042/bj2420931.
Abstract
Removal of the litter from lactating rats results in a fall in the rate of noradrenaline-stimulated lipolysis of adipocytes. This adaptation can be prevented by administration of growth hormone (somatotropin) to such rats and mimicked by injecting lactating rats with an antiserum to growth hormone, whereas lowering serum prolactin by injecting bromocriptine had no effect. The anti-lipolytic effect of adenosine is increased during lactation and is still increased by 2 days after litter removal. Injection of growth hormone into lactating rats decreased slightly the response to adenosine, whereas injection of growth hormone into rats after removal of their litters resulted in a much greater decrease in the response to adenosine, to that found in virgin and pregnant rats.
摘要
从哺乳期大鼠移除幼崽会导致脂肪细胞中去甲肾上腺素刺激的脂肪分解速率下降。给这些大鼠注射生长激素（促生长素）可防止这种适应性变化，而给哺乳期大鼠注射生长激素抗血清可模拟这种变化，而注射溴隐亭降低血清催乳素则没有效果。哺乳期腺苷的抗脂解作用增强，并且在移除幼崽后2天仍会增强。给哺乳期大鼠注射生长激素会使对腺苷的反应略有降低，而给移除幼崽后的大鼠注射生长激素会使对腺苷的反应比未生育和怀孕大鼠的反应降低得更多。
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Adenosine and the control of lipolysis in rat adipocytes during pregnancy and lactation.孕期和哺乳期大鼠脂肪细胞中腺苷与脂肪分解的调控
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