绵羊妊娠和哺乳期脂解作用的调节。对去甲肾上腺素和腺苷的反应。
Regulation of lipolysis during pregnancy and lactation in sheep. Response to noradrenaline and adenosine.
作者信息
Vernon R G, Finley E
出版信息
Biochem J. 1985 Sep 15;230(3):651-6. doi: 10.1042/bj2300651.
Abstract
The effects of pregnancy and lactation on lipolysis in sheep adipose tissue in vitro were investigated. Neither pregnancy nor lactation altered the basal rate of lipolysis. The rate of noradrenaline-stimulated lipolysis was directly proportional to adipocyte mean cell volume. Lactation, but not pregnancy, increased the response to noradrenaline, but had no effect on the ED50 of noradrenaline. The adenosine analogue N6-phenylisopropyladenosine decreased the rate of lipolysis in the presence of noradrenaline; the effect was greater with adipose tissue from lactating than from control, unmated, sheep. Results are discussed in relation to the need of sheep to mobilize lipid during early lactation to support milk production.
摘要
研究了妊娠和泌乳对绵羊体外脂肪组织脂解作用的影响。妊娠和泌乳均未改变基础脂解速率。去甲肾上腺素刺激的脂解速率与脂肪细胞平均细胞体积成正比。泌乳而非妊娠增加了对去甲肾上腺素的反应，但对去甲肾上腺素的半数有效剂量（ED50）没有影响。腺苷类似物N6-苯异丙基腺苷在有去甲肾上腺素存在的情况下降低了脂解速率；来自泌乳绵羊的脂肪组织比来自未交配的对照绵羊的脂肪组织对此作用更敏感。结合绵羊在泌乳早期动员脂质以支持产奶的需求对结果进行了讨论。
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1
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J Clin Endocrinol Metab. 1981 Feb;52(2):359-63. doi: 10.1210/jcem-52-2-359.
2
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Res Vet Sci. 1980 Jul;29(1):108-10.
3
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4
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