大鼠妊娠和哺乳期脂肪细胞中的脂肪分解。对去甲肾上腺素的反应。
Lipolysis in rat adipocytes during pregnancy and lactation. The response to noradrenaline.
作者信息
Aitchison R E, Clegg R A, Vernon R G
出版信息
Biochem J. 1982 Jan 15;202(1):243-7. doi: 10.1042/bj2020243.
Abstract
- Lipolysis has been measured in parametrial adipocytes from virgin, pregnant and lactating rats. 2. The basal rate and the maximal rate of lipolysis, the latter measured in the presence of noradrenaline and theophylline, remained constant between the three experimental categories, with the exception of a significant transient increase in the basal rate at parturition. 3. The noradrenaline-stimulated lipolysis rate rose above the virgin rate during pregnancy and fell below it during lactation; inclusion of adenosine deaminase in incubations abolished these differences in response to noradrenaline. 4. Cyclic AMP phosphodiesterase activity was lower in adipocytes during pregnancy and lactation than in virgin animals.
摘要
- 已对未孕、怀孕和哺乳期大鼠子宫旁脂肪细胞的脂肪分解进行了测定。2. 脂肪分解的基础速率和最大速率（后者在去甲肾上腺素和茶碱存在的情况下测定）在这三个实验类别之间保持恒定，但分娩时基础速率有显著的短暂增加。3. 去甲肾上腺素刺激的脂肪分解速率在怀孕期间高于未孕大鼠，在哺乳期低于未孕大鼠；在孵育中加入腺苷脱氨酶消除了对去甲肾上腺素反应的这些差异。4. 怀孕和哺乳期脂肪细胞中的环磷酸腺苷磷酸二酯酶活性低于未孕动物。
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本文引用的文献
1
A study of some aspects of reproduction by means of chemical analysis.
Br J Nutr. 1950;4(4):354-60. doi: 10.1079/bjn19500059.
2
A rapid enzymatic assay for glycerol.
Nature. 1962 Dec 8;196:987-8. doi: 10.1038/196987a0.
3
Protein metabolism in the pregnant rat.
J Nutr. 1954 Oct 11;54(2):291-304. doi: 10.1093/jn/54.2.291.
4
Altered lipolytic response to glucagon and adenosine deaminase in adipocytes from starved rats.
Biochem J. 1980 Jun 15;188(3):757-61. doi: 10.1042/bj1880757.
5
Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat.
Biochem J. 1981 Aug 15;198(2):425-8. doi: 10.1042/bj1980425.
6
Role of adenosine in adipose tissue circulation.
Acta Physiol Scand. 1981 Jul;112(3):293-8. doi: 10.1111/j.1748-1716.1981.tb06819.x.
7
The release of adenosine and inosine from canine subcutaneous adipose tissue by nerve stimulation and noradrenaline.
J Physiol. 1981;313:351-67. doi: 10.1113/jphysiol.1981.sp013670.
8
Citrate, pyruvate, and lactate contaminants of commercial serum albumin.
J Lipid Res. 1968 Sep;9(5):667-8.
9
The significance of changes in tissue clearing-factor lipase activity in relation to the lipaemia of pregnancy.
Biochem J. 1968 Feb;106(3):677-82. doi: 10.1042/bj1060677.
10
Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats.
Biochim Biophys Acta. 1970 Sep 8;210(3):473-82. doi: 10.1016/0005-2760(70)90044-5.
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