大鼠妊娠和哺乳期脂肪细胞中的脂肪分解。对去甲肾上腺素的反应。
Lipolysis in rat adipocytes during pregnancy and lactation. The response to noradrenaline.
作者信息
Aitchison R E, Clegg R A, Vernon R G
出版信息
Biochem J. 1982 Jan 15;202(1):243-7. doi: 10.1042/bj2020243.
Abstract
- Lipolysis has been measured in parametrial adipocytes from virgin, pregnant and lactating rats. 2. The basal rate and the maximal rate of lipolysis, the latter measured in the presence of noradrenaline and theophylline, remained constant between the three experimental categories, with the exception of a significant transient increase in the basal rate at parturition. 3. The noradrenaline-stimulated lipolysis rate rose above the virgin rate during pregnancy and fell below it during lactation; inclusion of adenosine deaminase in incubations abolished these differences in response to noradrenaline. 4. Cyclic AMP phosphodiesterase activity was lower in adipocytes during pregnancy and lactation than in virgin animals.
摘要
- 已对未孕、怀孕和哺乳期大鼠子宫旁脂肪细胞的脂肪分解进行了测定。2. 脂肪分解的基础速率和最大速率（后者在去甲肾上腺素和茶碱存在的情况下测定）在这三个实验类别之间保持恒定，但分娩时基础速率有显著的短暂增加。3. 去甲肾上腺素刺激的脂肪分解速率在怀孕期间高于未孕大鼠，在哺乳期低于未孕大鼠；在孵育中加入腺苷脱氨酶消除了对去甲肾上腺素反应的这些差异。4. 怀孕和哺乳期脂肪细胞中的环磷酸腺苷磷酸二酯酶活性低于未孕动物。
相似文献
1
Lipolysis in rat adipocytes during pregnancy and lactation. The response to noradrenaline.大鼠妊娠和哺乳期脂肪细胞中的脂肪分解。对去甲肾上腺素的反应。
Biochem J. 1982 Jan 15;202(1):243-7. doi: 10.1042/bj2020243.
2
Adenosine and the control of lipolysis in rat adipocytes during pregnancy and lactation.孕期和哺乳期大鼠脂肪细胞中腺苷与脂肪分解的调控
Biochem J. 1983 Oct 15;216(1):121-8. doi: 10.1042/bj2160121.
3
Lipolysis in rat adipocytes during recovery from lactation. Response to noradrenaline and adenosine.大鼠脂肪细胞在从哺乳期恢复过程中的脂肪分解。对去甲肾上腺素和腺苷的反应。
Biochem J. 1986 Feb 15;234(1):229-31. doi: 10.1042/bj2340229.
4
Changes in the sensitivity to glucagon of lipolysis in adipocytes from pregnant and lactating rats.妊娠和哺乳期大鼠脂肪细胞中脂解作用对胰高血糖素敏感性的变化。
Biochem J. 1988 Sep 15;254(3):661-5. doi: 10.1042/bj2540661.
5
Regulation of lipolysis during pregnancy and lactation in sheep. Response to noradrenaline and adenosine.绵羊妊娠和哺乳期脂解作用的调节。对去甲肾上腺素和腺苷的反应。
Biochem J. 1985 Sep 15;230(3):651-6. doi: 10.1042/bj2300651.
6
Quantitative relationships between cyclic adenosine-3',5'-monophosphate and lipolysis in adipose tissue during the peripartum period.
J Dairy Sci. 1992 Jul;75(7):1901-13. doi: 10.3168/jds.S0022-0302(92)77950-8.
7
Role of growth hormone in the adaptations of lipolysis in rat adipocytes during recovery from lactation.生长激素在大鼠脂肪细胞从哺乳期恢复过程中脂肪分解适应性变化中的作用。
Biochem J. 1987 Mar 15;242(3):931-4. doi: 10.1042/bj2420931.
8
Uncoupling of lipolysis from cyclic AMP by procaine: a tool for studying the mechanism of action of antilipolytic agents.普鲁卡因使脂解作用与环磷酸腺苷解偶联：一种研究抗脂解剂作用机制的工具。
Can J Physiol Pharmacol. 1975 Aug;53(4):603-9. doi: 10.1139/y75-084.
9
Selective effects of phosphodiesterase inhibitors on different phosphodiesterases, adenosine 3',5'-monophosphate metabolism, and lipolysis in 3T3-L1 adipocytes.磷酸二酯酶抑制剂对3T3-L1脂肪细胞中不同磷酸二酯酶、3',5'-环磷酸腺苷代谢及脂肪分解的选择性作用。
Endocrinology. 1984 Oct;115(4):1262-8. doi: 10.1210/endo-115-4-1262.
10
Evolution of the sensitivity of isolated adipocytes of ewes to the lipolytic effects of different stimuli during pregnancy and lactation.
Int J Biochem. 1987;19(3):253-8. doi: 10.1016/0020-711x(87)90028-0.
引用本文的文献
1
Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes.Widdrol诱导的脂肪分解由3T3-L1脂肪细胞中的蛋白激酶C（PKC）和丝裂原活化蛋白激酶/细胞外信号调节激酶（MEK/ERK）介导。
Mol Cell Biochem. 2015 Dec;410(1-2):247-54. doi: 10.1007/s11010-015-2558-0. Epub 2015 Sep 10.
2
Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes.阿西莫司在离体大鼠脂肪细胞中的抗脂解作用机制。
Diabetologia. 1996 Jan;39(1):45-53. doi: 10.1007/BF00400412.
3
Mechanisms involved in the adaptations of the adipocyte adrenergic signal-transduction system and their modulation by growth hormone during the lactation cycle in the rat.大鼠泌乳周期中脂肪细胞肾上腺素能信号转导系统适应性变化的机制及其受生长激素的调节。
Biochem J. 1993 Feb 1;289 ( Pt 3)(Pt 3):845-51. doi: 10.1042/bj2890845.
4
Effects of lactation on the signal transduction systems regulating lipolysis in sheep subcutaneous and omental adipose tissue.泌乳对调节绵羊皮下和网膜脂肪组织脂肪分解的信号转导系统的影响。
Biochem J. 1995 May 15;308 ( Pt 1)(Pt 1):291-6. doi: 10.1042/bj3080291.
5
Changes in the anti-lipolytic action and binding to plasma membranes of N6-L-phenylisopropyladenosine in adipocytes from starved and hypothyroid rats.饥饿和甲状腺功能减退大鼠脂肪细胞中N6-L-苯异丙基腺苷的抗脂解作用及与质膜结合的变化。
Biochem J. 1984 Oct 1;223(1):53-9. doi: 10.1042/bj2230053.
6
Adenosine and the control of lipolysis in rat adipocytes during pregnancy and lactation.孕期和哺乳期大鼠脂肪细胞中腺苷与脂肪分解的调控
Biochem J. 1983 Oct 15;216(1):121-8. doi: 10.1042/bj2160121.
7
Inhibition of lipolysis by adenosine is potentiated with age.随着年龄增长，腺苷对脂肪分解的抑制作用增强。
J Clin Invest. 1984 Nov;74(5):1750-5. doi: 10.1172/JCI111593.
8
Regulation of lipolysis during pregnancy and lactation in sheep. Response to noradrenaline and adenosine.绵羊妊娠和哺乳期脂解作用的调节。对去甲肾上腺素和腺苷的反应。
Biochem J. 1985 Sep 15;230(3):651-6. doi: 10.1042/bj2300651.
9
Effect of adenosine deaminase, N6-phenylisopropyladenosine and hypothyroidism on the responsiveness of rat brown adipocytes to noradrenaline.腺苷脱氨酶、N6-苯异丙基腺苷及甲状腺功能减退对大鼠棕色脂肪细胞对去甲肾上腺素反应性的影响。
Biochem J. 1986 Sep 1;238(2):395-403. doi: 10.1042/bj2380395.
10
Lipolysis in rat adipocytes during recovery from lactation. Response to noradrenaline and adenosine.大鼠脂肪细胞在从哺乳期恢复过程中的脂肪分解。对去甲肾上腺素和腺苷的反应。
Biochem J. 1986 Feb 15;234(1):229-31. doi: 10.1042/bj2340229.
本文引用的文献
1
A study of some aspects of reproduction by means of chemical analysis.一项通过化学分析对生殖某些方面进行的研究。
Br J Nutr. 1950;4(4):354-60. doi: 10.1079/bjn19500059.
2
A rapid enzymatic assay for glycerol.一种用于甘油的快速酶促测定法。
Nature. 1962 Dec 8;196:987-8. doi: 10.1038/196987a0.
3
Protein metabolism in the pregnant rat.怀孕大鼠的蛋白质代谢
J Nutr. 1954 Oct 11;54(2):291-304. doi: 10.1093/jn/54.2.291.
4
Altered lipolytic response to glucagon and adenosine deaminase in adipocytes from starved rats.饥饿大鼠脂肪细胞对胰高血糖素和腺苷脱氨酶的脂解反应改变。
Biochem J. 1980 Jun 15;188(3):757-61. doi: 10.1042/bj1880757.
5
Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat.大鼠妊娠晚期母体和胎儿组织中的体内脂肪生成。
Biochem J. 1981 Aug 15;198(2):425-8. doi: 10.1042/bj1980425.
6
Role of adenosine in adipose tissue circulation.腺苷在脂肪组织循环中的作用。
Acta Physiol Scand. 1981 Jul;112(3):293-8. doi: 10.1111/j.1748-1716.1981.tb06819.x.
7
The release of adenosine and inosine from canine subcutaneous adipose tissue by nerve stimulation and noradrenaline.通过神经刺激和去甲肾上腺素从犬皮下脂肪组织中释放腺苷和肌苷。
J Physiol. 1981;313:351-67. doi: 10.1113/jphysiol.1981.sp013670.
8
Citrate, pyruvate, and lactate contaminants of commercial serum albumin.商业血清白蛋白中的柠檬酸盐、丙酮酸和乳酸盐污染物。
J Lipid Res. 1968 Sep;9(5):667-8.
9
The significance of changes in tissue clearing-factor lipase activity in relation to the lipaemia of pregnancy.组织清除因子脂肪酶活性变化与妊娠脂血症的关系
Biochem J. 1968 Feb;106(3):677-82. doi: 10.1042/bj1060677.
10
Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats.妊娠和哺乳期大鼠脂肪组织、乳腺组织的脂蛋白脂肪酶活性及血浆甘油三酯水平
Biochim Biophys Acta. 1970 Sep 8;210(3):473-82. doi: 10.1016/0005-2760(70)90044-5.
Zotero 插件