Engle M J, Dooley M, Brown D J
Biochem Biophys Res Commun. 1987 May 29;145(1):397-401. doi: 10.1016/0006-291x(87)91335-0.
Fetal rabbit lungs from 23 day gestation animals were used to investigate the potential role of lactate as a substrate for fetal lung glycogen synthesis. Fetal lactate dehydrogenase activity was approximately twice that found in the adult lung, while the activity of phosphoenolpyruvate carboxykinase was elevated fourfold over the adult value. Pyruvate carboxylase activities were similar in both fetal and adult lungs. Studies employing fetal lung explants in organ culture indicated that the presence of both glucose and lactate may be necessary for glycogen accumulation in the developing fetal lung. These data support the hypothesis that lactate is an important precursor for fetal lung glycogen.
使用来自妊娠23天动物的胎兔肺来研究乳酸作为胎肺糖原合成底物的潜在作用。胎儿乳酸脱氢酶活性约为成年肺中的两倍，而磷酸烯醇式丙酮酸羧激酶的活性比成年值高四倍。丙酮酸羧化酶活性在胎儿和成年肺中相似。在器官培养中使用胎儿肺外植体的研究表明，葡萄糖和乳酸的存在可能是发育中的胎儿肺中糖原积累所必需的。这些数据支持乳酸是胎儿肺糖原重要前体的假说。
