Department of Chemistry, Federal University of Technology, Akure, Nigeria.
Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
J Food Biochem. 2022 Nov;46(11):e14373. doi: 10.1111/jfbc.14373. Epub 2022 Aug 7.
The effects of dietary inclusion of Bambara groundnut and sweet orange peels composite bread on low-dose streptozotocin and high-fat diet (HFD)-induced type-2 diabetes mellitus (T2D) complications was evaluated in the present study. Male experimental rats-induced T2D were administered with acarbose (standard) and fed with Bambara groundnut and sweet orange peels composite bread for a period of 14 days while monitoring their blood glucose levels. More so, the activities of angiotensin-I-converting enzyme (ACE), serum aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase activities, as well as nitric oxide (NO), reactive oxygen species (ROS), albumin, total bilirubin, creatinine, urea, and uric acid serum concentrations were assayed for. Diabetic untreated rats showed disorders in ACE, AST, ALT, and ALP activities, and NO, ROS, glucose, albumin, bilirubin, creatinine, urea, uric acid levels, as well as lipid profiles. Interestingly, these disorders were significantly ameliorated in composite bread diet-fed rats in comparison to the diabetic untreated rats. Meanwhile, the presence of polyphenols in the Bambara groundnut and sweet orange peels composite bread diet could have aided the amelioration of these metabolic disorders after the 14th day of administration. Finally, it was proposed that the ability of Bambara groundnut-wheat and sweet orange peel composite bread to treat T2D and its complications makes it a more successful therapy than medications that just target one of the diseased states. PRACTICAL APPLICATIONS: Diabetes mellitus is a global and chronic disease that presently affects 536.6 million people alongside 1.5 million deaths directly attributed to it yearly. Several drug and medicinal agents have been employed for the management of diabetes but those drugs are mostly limited to the management of diabetes while the associated complications are most untreated, while drugs that can manage diabetes and its related complications mostly come at high prices. Therefore, there is an urgent need to evaluate legumes, such as Bambara groundnut, with proven therapeutic potential in the management of diabetes and its complications. However, the Bambara groundnut takes a long period to prepare for a meal, therefore including it in a ready-to-eat product will not only improve its acceptability but also add to economic improvement. Furthermore, adding a waste product, sweet orange peels, will both add flavor and source of additional antioxidant attributes.
本研究评估了在低剂量链脲佐菌素和高脂肪饮食（HFD）诱导的 2 型糖尿病（T2D）模型中，斑鸠菊-甜橙皮复合面包对饮食的影响。患有 T2D 的雄性实验大鼠给予阿卡波糖（标准）并喂食斑鸠菊-甜橙皮复合面包 14 天，同时监测其血糖水平。此外，还测定了血管紧张素转化酶（ACE）、血清天冬氨酸氨基转移酶、碱性磷酸酶和丙氨酸氨基转移酶的活性以及一氧化氮（NO）、活性氧（ROS）、白蛋白、总胆红素、肌酐、尿素和尿酸的血清浓度。未治疗的糖尿病大鼠 ACE、AST、ALT 和 ALP 活性以及 NO、ROS、葡萄糖、白蛋白、胆红素、肌酐、尿素和尿酸水平以及血脂谱均出现紊乱。有趣的是，与未治疗的糖尿病大鼠相比，复合面包饮食喂养的大鼠这些紊乱得到了显著改善。同时，斑鸠菊-甜橙皮复合面包中多酚的存在可能有助于在给药第 14 天后改善这些代谢紊乱。最后，研究提出，与仅针对一种疾病状态的药物相比，斑鸠菊-小麦和甜橙皮复合面包治疗 T2D 及其并发症的能力使其成为一种更成功的治疗方法。 实际应用：糖尿病是一种全球性和慢性疾病，目前全球有 5366.6 万人患有糖尿病，每年有 150 万人直接死于糖尿病。已经使用了几种药物和药物来治疗糖尿病，但这些药物大多仅限于糖尿病的管理，而相关的并发症大多未得到治疗，而能够管理糖尿病及其相关并发症的药物大多价格昂贵。因此，迫切需要评估斑鸠豆等具有治疗糖尿病及其并发症的潜在治疗作用的豆类。然而，斑鸠豆需要很长时间才能准备好一顿饭，因此将其纳入即食产品不仅可以提高其可接受性，还可以提高经济效益。此外，添加一种废物甜橙皮不仅可以增加风味，还可以增加额外的抗氧化属性。
