García-Torres José, Colombi Samuele, Macor Lorena P, Alemán Carlos
Biomaterials, Biomechanics and Tissue Engineering Group, Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, 08930 Barcelona, Spain.
Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, 08019 Barcelona, Spain.
Int J Biol Macromol. 2022 Oct 31;219:312-332. doi: 10.1016/j.ijbiomac.2022.08.008. Epub 2022 Aug 5.
Poly(3,4-ethylenedioxythiophene) (PEDOT), a very stable and biocompatible conducting polymer, and alginate (Alg), a natural water-soluble polysaccharide mainly found in the cell wall of various species of brown algae, exhibit very different but at the same complementary properties. In the last few years, the remarkable capacity of Alg to form hydrogels and the electro-responsive properties of PEDOT have been combined to form not only layered composites (PEDOT-Alg) but also interpenetrated multi-responsive PEDOT/Alg hydrogels. These materials have been found to display outstanding properties, such as electrical conductivity, piezoelectricity, biocompatibility, self-healing and re-usability properties, pH and thermoelectric responsiveness, among others. Consequently, a wide number of applications are being proposed for PEDOT-Alg composites and, especially, PEDOT/Alg hydrogels, which should be considered as a new kind of hybrid material because of the very different chemical nature of the two polymeric components. This review summarizes the applications of PEDOT-Alg and PEDOT/Alg in tissue interfaces and regeneration, drug delivery, sensors, microfluidics, energy storage and evaporators for desalination. Special attention has been given to the discussion of multi-tasking applications, while the new challenges to be tackled based on aspects not yet considered in either of the two polymers have also been highlighted.
聚（3,4-乙撑二氧噻吩）（PEDOT）是一种非常稳定且具有生物相容性的导电聚合物，而藻酸盐（Alg）是一种主要存在于各种褐藻细胞壁中的天然水溶性多糖，它们表现出截然不同但又互补的性质。在过去几年中，Alg形成水凝胶的显著能力与PEDOT的电响应特性相结合，不仅形成了层状复合材料（PEDOT-Alg），还形成了互穿的多响应PEDOT/Alg水凝胶。已发现这些材料具有出色的性能，如导电性、压电性、生物相容性、自愈性和可重复使用性、pH值和热电响应性等。因此，人们提出了许多PEDOT-Alg复合材料，特别是PEDOT/Alg水凝胶的应用，由于这两种聚合物组分的化学性质截然不同，它们应被视为一种新型的混合材料。本文综述了PEDOT-Alg和PEDOT/Alg在组织界面与再生、药物递送、传感器、微流体、能量存储和海水淡化蒸发器中的应用。特别关注了多任务应用的讨论，同时也强调了基于这两种聚合物尚未考虑的方面需要应对的新挑战。
