Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/ Eduard Maristany, 10-14, Barcelona 08019, Spain.
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Barcelona 08930, Spain.
ACS Biomater Sci Eng. 2020 Nov 9;6(11):6228-6240. doi: 10.1021/acsbiomaterials.0c01400. Epub 2020 Oct 8.
Stimuli-responsive biomaterials have attracted significant attention for the construction of on-demand drug release systems. The possibility of using external stimulation to trigger drug release is particularly enticing for hydrophobic compounds, which are not easily released by simple diffusion. In this work, an electrochemically active hydrogel, which has been prepared by gelling a mixture of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and alginate (Alg), has been loaded with curcumin (CUR), a hydrophobic drug with a wide spectrum of clinical applications. The PEDOT/Alg hydrogel is electrochemically active and organizes as segregated PEDOT- and Alg-rich domains, explaining its behavior as an electroresponsive drug delivery system. When loaded with CUR, the hydrogel demonstrates a controlled drug release upon application of a negative electrical voltage. Comparison with the release profiles obtained applying a positive voltage and in the absence of electrical stimuli indicates that the release mechanism dominating this system is complex because of not only the intermolecular interactions between the drug and the polymeric network but also the loading of a hydrophobic drug in a water-containing delivery system.
刺激响应型生物材料在构建按需药物释放系统方面引起了广泛关注。对于疏水性化合物，使用外部刺激触发药物释放的可能性特别诱人，因为这些化合物不容易通过简单的扩散释放。在这项工作中，通过将聚(3,4-乙二氧基噻吩)：聚苯乙烯磺酸盐 (PEDOT:PSS) 和藻酸盐 (Alg) 的混合物凝胶化，制备了一种电化学活性水凝胶，该水凝胶负载了姜黄素 (CUR)，这是一种具有广泛临床应用的疏水性药物。PEDOT/Alg 水凝胶具有电化学活性，并组织为分离的 PEDOT 和 Alg 丰富域，解释了其作为电响应药物递送系统的行为。当负载 CUR 时，水凝胶在施加负电压时表现出受控的药物释放。与施加正电压和没有电刺激获得的释放曲线进行比较表明，由于药物与聚合物网络之间的分子间相互作用以及疏水性药物在含水递送系统中的负载，该系统的释放机制很复杂。
