Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Environ Res. 2022 Nov;214(Pt 3):114031. doi: 10.1016/j.envres.2022.114031. Epub 2022 Aug 4.
Studies on associations of metals with leucocyte telomere length (LTL) were mainly limited to several most common toxic metals and single-metal effect, but the impact of other common metals and especially the overall joint associations and interactions of metal mixture with LTL are largely unknown. We included 15 plasma metals and LTL among 4906 participants from Dongfeng-Tongji cohort. Multivariable linear regression was used to estimate associations of individual metals with LTL. We also applied Bayesian kernel machine regression (BKMR) and quantile g-computation regression (Q-g) to evaluate the overall association and interactions, and identified the major contributors as well as the potential modifications by major characteristics. Multivariable linear regression found vanadium, copper, arsenic, aluminum and nickel were negatively associated with LTL, and a 2-fold change was related to 1.9%-5.1% shorter LTL; while manganese and zinc showed 3.7% and 4.0% longer LTL (all P < 0.05) in multiple-metal models. BKMR confirmed above metals and revealed a linearly inverse joint association between 15 metals and LTL. Q-g regression further indicated each quantile increase in mixture was associated with 5.2% shorter LTL (95% CI: -8.1%, -2.3%). Furthermore, manganese counteracted against aluminum and vanadium respectively (P<0.05). In addition, associations of vanadium, aluminum and metal mixture with LTL were more prominent in overweight participants. Our results are among the first to provide a new comprehensive view of metal mixture exposure on LTL attrition in the general population, including identifying the major components, metals interactions and the overall effects.
关于金属与白细胞端粒长度（LTL）之间关联的研究主要局限于几种最常见的有毒金属和单一金属效应，但其他常见金属的影响，尤其是金属混合物与 LTL 之间的整体联合关联和相互作用在很大程度上尚不清楚。我们纳入了来自东风-同济队列的 4906 名参与者中的 15 种血浆金属和 LTL。多变量线性回归用于估计单个金属与 LTL 的关联。我们还应用贝叶斯核机器回归（BKMR）和分位数 g 计算回归（Q-g）来评估整体关联和相互作用，并确定主要贡献者以及主要特征的潜在修饰作用。多变量线性回归发现，钒、铜、砷、铝和镍与 LTL 呈负相关，2 倍变化与 LTL 缩短 1.9%-5.1%有关；而锰和锌在多金属模型中显示 LTL 延长 3.7%和 4.0%（均 P<0.05）。BKMR 证实了上述金属，并显示 15 种金属与 LTL 之间呈线性负相关的联合关系。Q-g 回归进一步表明，混合物每个分位数的增加与 LTL 缩短 5.2%（95%CI：-8.1%，-2.3%）相关。此外，锰分别与铝和钒相互拮抗（P<0.05）。此外，在超重参与者中，钒、铝和金属混合物与 LTL 之间的关联更为显著。我们的研究结果首次提供了一种新的全面视角，即研究一般人群中金属混合物暴露对 LTL 损耗的影响，包括确定主要成分、金属相互作用和整体效应。
