Rong Jiahui, Liu Qiumei, Zhang Tiantian, Lu Yufu, Ye Zeyan, Teng Kaisheng, Luo Lei, Wu Songju, Zhao Linhai, Jin Wenjia, Guan Qinyi, Li You, Qin Jian, Cai Jiansheng, Zhang Zhiyong
Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, PR China.
Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, PR China.
Sci Rep. 2025 Mar 11;15(1):8387. doi: 10.1038/s41598-025-93216-w.
This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations. In the 30-59 age group, the overall metal mixture was significantly negatively associated with rTL (estimate = -0.069, P = 0.003), with Zn as the dominant contributor. In the elderly, the metal mixture was positively associated with rTL (estimate = 0.040, P = 0.031), with Cr and Mn as main contributors. The findings highlight the importance of maintaining adequate Cr and Mn levels in older adults, and the potential adverse impact of Cu, Mo, and Zn on telomere length.
本研究调查了2194名年龄≥30岁的中国成年人血浆中必需金属元素（钴、铬、铜、锰、钼、硒、锌）与端粒长度之间的关系。使用电感耦合等离子体质谱法测量金属浓度，通过定量聚合酶链反应评估白细胞相对端粒长度（rTL）。在老年人中，铬和锰与rTL呈显著正相关，而钼、锌和铜呈负相关。在30 - 59岁年龄组中，总体金属混合物与rTL呈显著负相关（估计值=-0.069，P = 0.003），锌是主要贡献因素。在老年人中，金属混合物与rTL呈正相关（估计值=0.040，P = 0.031），铬和锰是主要贡献因素。研究结果突出了维持老年人足够铬和锰水平的重要性，以及铜、钼和锌对端粒长度的潜在不利影响。
