Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, European Union Reference Laboratory for Residues, P.O. Box 230, 6700 AE, Wageningen, the Netherlands.
Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, European Union Reference Laboratory for Residues, P.O. Box 230, 6700 AE, Wageningen, the Netherlands.
Anal Chim Acta. 2022 Aug 22;1222:340039. doi: 10.1016/j.aca.2022.340039. Epub 2022 Jun 8.
Ion mobility spectrometry (IMS) is gaining importance in the field of food safety and authenticity in recent years due to its main potential to overcome the challenges that arise from the complexity of food matrices. For many years, IMS has been used as a stand-alone analytical detector due to its quick response, high sensitivity, and portability, and stand-alone applications in food analysis have been explored in recent years. At the same time, IMS hyphenation to mass spectrometry (MS) techniques, usually combined with liquid or gas chromatography (LC/GC), provides an additional dimension to separate isobaric compounds and thus improves method selectivity. Besides, with such ion mobility - mass spectrometry (IM-MS) methods, background noise decreases, increasing method sensitivity, and it provides complementary information to mass spectra and retention time with the collision cross section (CCS). The development of CCS databases within the food safety field would even permit the identification of compounds in non-targeted approaches. Furthermore, it would increase the confidence of control laboratories when determining a sample as non-compliant. Therefore, the number of applications by IMS on food safety and authenticity has increased remarkably in recent years. This review provides the general insights of IMS with the current state and recent approaches for its performance improvement and a general outlook of its applicability in food safety and authenticity.
近年来，离子迁移谱（IMS）因其克服食品基质复杂性带来的挑战的主要潜力，在食品安全和真实性领域的重要性日益增加。多年来，IMS 因其快速响应、高灵敏度和便携性而被用作独立的分析检测器，近年来已经探索了其在食品分析中的独立应用。与此同时，IMS 与质谱（MS）技术的联用，通常与液相或气相色谱（LC/GC）联用，为分离等摩尔化合物提供了另一个维度，从而提高了方法的选择性。此外，采用这种离子迁移-质谱（IM-MS）方法，背景噪声降低，提高了方法的灵敏度，并提供了与质荷比和保留时间相关的碰撞截面（CCS）的补充信息。在食品安全领域建立 CCS 数据库甚至可以允许在非靶向方法中识别化合物。此外，这将增加控制实验室在确定样品不合格时的信心。因此，近年来，IMS 在食品安全和真实性方面的应用数量显著增加。本综述提供了 IMS 的一般见解，包括其当前状态和最近的性能改进方法，以及其在食品安全和真实性中的适用性的总体展望。
