Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Microbiology, Immunology, and Molecular Genetics, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA.
Trends Cell Biol. 2023 Feb;33(2):112-123. doi: 10.1016/j.tcb.2022.07.003. Epub 2022 Aug 4.
Stem cell niches are composed of dynamic microenvironments that support stem cells over a lifetime. The emerging niche is distinct from the adult because its main role is to support the progenitors that build organ systems in development. Emerging niches mature through distinct stages to form the adult niche and enable proper stem cell support. As a model of emerging niches, this review highlights how differences in the skeletal muscle microenvironment influence emerging versus satellite cell (SC) niche formation in skeletal muscle, which is among the most regenerative tissue systems. We contrast how stem cell niches regulate intrinsic properties between progenitor and stem cells throughout development to adulthood. We describe new applications for generating emerging niches from human pluripotent stem cells (hPSCs) using developmental principles and highlight potential applications for regeneration and therapeutics.
干细胞龛由支持干细胞一生的动态微环境组成。新兴的龛不同于成人的龛，因为它的主要作用是支持祖细胞，祖细胞在发育过程中构建器官系统。新兴龛通过不同的阶段成熟，形成成年龛，并为适当的干细胞支持提供条件。作为新兴龛的一个模型，本综述强调了骨骼肌肉微环境的差异如何影响骨骼肌肉中新兴龛与卫星细胞（SC）龛的形成，骨骼肌肉是最具再生能力的组织系统之一。我们比较了干细胞龛如何在整个发育和成年过程中调节祖细胞和干细胞之间的内在特性。我们描述了如何使用发育原理从人多能干细胞（hPSCs）中生成新兴龛，并强调了其在再生和治疗方面的潜在应用。
