Rodgers J B, Slowinska R, Bochenek W J
Atherosclerosis. 1987 Mar;64(1):37-46. doi: 10.1016/0021-9150(87)90052-9.
Studies were performed in hypercholesterolemic rabbits to determine whether the hydrophobic surfactant, Poloxalene 2930 (Pol), is of benefit under these conditions. Lipoprotein analyses plus chemical and morphologic studies of the aorta were performed to evaluate the results. In one study, rabbits were made hypercholesterolemic by dietary means and then divided into two groups and given a cholesterol-free diet with one group additionally given Pol with treatment continued for 10 weeks. Pol treatment resulted in less atherosclerosis but the mechanism for this effect was not apparent from lipoprotein analysis. In the other study 3 groups of rabbits were given a cholesterol-rich diet for 16 weeks. Two groups received Pol supplement with one of these groups receiving a dose that was too small to prevent hypercholesterolemia. In this group plus the group on diet alone comparable degrees of hypercholesterolemia were maintained throughout the study. Lipoprotein abnormalities were similar in these two groups except that those on Pol had a more normal cholesterol to apolipoprotein B ratio. The amount of atherosclerosis in both groups was mild but aortic cholesterol content was much less for the Pol group. It is concluded that Pol limits cholesterol accumulation in the aortic wall of hypercholesterolemic rabbits and can retard the development of atherosclerosis.
在高胆固醇血症兔身上进行了研究，以确定疏水性表面活性剂泊洛沙林2930（Pol）在这些情况下是否有益。进行了脂蛋白分析以及主动脉的化学和形态学研究以评估结果。在一项研究中，通过饮食使兔产生高胆固醇血症，然后将其分为两组并给予无胆固醇饮食，其中一组额外给予Pol，治疗持续10周。Pol治疗导致动脉粥样硬化减轻，但脂蛋白分析未显示出这种作用的机制。在另一项研究中，3组兔给予富含胆固醇的饮食16周。两组接受Pol补充剂，其中一组接受的剂量过小，无法预防高胆固醇血症。在该组以及仅接受饮食的组中，在整个研究过程中维持了相当程度的高胆固醇血症。这两组的脂蛋白异常情况相似，只是服用Pol的组胆固醇与载脂蛋白B的比例更正常。两组的动脉粥样硬化程度均较轻，但Pol组的主动脉胆固醇含量要低得多。得出的结论是，Pol可限制高胆固醇血症兔主动脉壁中胆固醇的积累，并可延缓动脉粥样硬化的发展。
