Kapuscinska B, Bochenek W J, Peng S K, Rodgers J B
Atherosclerosis. 1985 Nov;57(2-3):149-58. doi: 10.1016/0021-9150(85)90028-0.
Poloxalene 2930, a hydrophobic surfactant, was incorporated into an atherogenic diet at dose levels, 0.5% and 1% of the diet, and fed to rabbits for 10 weeks. Another group received plain atherogenic diet alone and a control group was fed chow. After this period, serum lipoproteins were separated by centrifugation and analyzed. The composition of lipoproteins from rabbits on atherogenic diet was abnormal. The cholesterol: triglyceride ratio of every lipoprotein fraction was significantly increased as was the cholesterol: protein ratio of very low density lipoproteins. Supplementing the diet with Poloxalene 2930 prevented these alterations. In all groups on the atherogenic diet the percentage of apolipoprotein E in VLDL and HDL increased. In the case of Poloxalene-treated rabbits this developed even though serum cholesterol levels were normal or slightly increased. It is concluded that Poloxalene 2930 has a systemic effect on lipoproteins which may contribute to its antiatherogenic action.
泊洛沙林2930是一种疏水表面活性剂，以饮食剂量的0.5%和1%添加到致动脉粥样化饮食中，喂养兔子10周。另一组仅接受普通致动脉粥样化饮食，对照组喂食普通食物。在此期间过后，通过离心分离血清脂蛋白并进行分析。食用致动脉粥样化饮食的兔子的脂蛋白组成异常。每个脂蛋白组分的胆固醇：甘油三酯比率显著升高，极低密度脂蛋白的胆固醇：蛋白质比率也如此。在饮食中添加泊洛沙林2930可防止这些改变。在所有食用致动脉粥样化饮食的组中，极低密度脂蛋白和高密度脂蛋白中载脂蛋白E的百分比增加。在泊洛沙林处理的兔子中，即使血清胆固醇水平正常或略有升高，这种情况也会出现。得出的结论是，泊洛沙林2930对脂蛋白有全身作用，这可能有助于其抗动脉粥样硬化作用。
