肌少症严重程度与稳定期精神分裂症患者肺炎的相关性：一项前瞻性研究。
Association between the Severity of Sarcopenia and Pneumonia in Patients with Stable Schizophrenia: A Prospective Study.
机构信息
Youguo Tan, MD, Southwest Medical University Zigong Affiliated Hospital, Zigong, Sichuan Province, China; Email:
出版信息
J Nutr Health Aging. 2022;26(8):799-805. doi: 10.1007/s12603-022-1830-8.
OBJECTIVES
This study investigates the associations between the severity of sarcopenia and pneumonia in patients with stable schizophrenia.
MATERIALS AND METHODS
This is a prospective study that includes patients from the rehabilitation wards of two mental health centres in western China, who were diagnosed with stable schizophrenia. Baseline data were collected from these patients between September 1 and September 30, 2020, while patients' data associated with pneumonia, diagnosed and treated by clinicians, were collected between October 2020 and October 2021. The severity of sarcopenia was diagnosed according to the diagnostic criteria defined by the Asian Working Group for Sarcopenia (AWGS) 2019. The association between the severity of sarcopenia and pneumonia in patients with schizophrenia was analyzed with the use of logistic regression analysis.
RESULTS
Three hundred and thirty-five patients with stable schizophrenia were enrolled in the prospective study, among whom 242 (72.24%) were≥60 years old, and 229 (68.36%) were males. Among the patients with stable schizophrenia, 130 (38.8%) were diagnosed with non-severe sarcopenia, whereas 47 (14.0%) had severe sarcopenia. Eighty-two (24.5%) of patients with schizophrenia fought pneumonia. Our study showed that the severe sarcopenia group had the highest incidence of pneumonia, followed by the non-severe sarcopenia group (severe sarcopenia vs. non-severe sarcopenia vs. normal, 38.3% vs. 28.46% vs. 17.09%, p=0.005). Compared with the normal group, the non-severe sarcopenia group (OR=1.93, 95%CI: 1.1-3.389) and the severe sarcopenia group (OR=3.011, 95%CI: 1.467-6.183) had a higher risk of pneumonia. We further adjusted the potential confounders such as sex, smoking history, chronic obstructive pulmonary disease (COPD), Patient Health Questionnaire (PHQ-9) score, and benzhexol and confirmed that only the severe sarcopenia group had an increased risk of pneumonia (OR=2.366, 95%CI: 1.078-5.191).
CONCLUSIONS
We have demonstrated that severe sarcopenia was associated with pneumonia in patients diagnosed with stable schizophrenia.
目的
本研究旨在探讨稳定期精神分裂症患者中肌少症严重程度与肺炎的相关性。
材料与方法
这是一项前瞻性研究，纳入了来自中国西部两家精神卫生中心康复病房的稳定期精神分裂症患者。于 2020 年 9 月 1 日至 9 月 30 日期间收集基线数据，于 2020 年 10 月至 2021 年 10 月期间收集与临床医生诊断和治疗的肺炎相关的数据。根据 2019 年亚洲肌少症工作组（AWGS）的诊断标准诊断肌少症严重程度。采用 logistic 回归分析评估精神分裂症患者肌少症严重程度与肺炎的相关性。
结果
本前瞻性研究共纳入 335 例稳定期精神分裂症患者，其中 242 例（72.24%）患者年龄≥60 岁，229 例（68.36%）患者为男性。在稳定期精神分裂症患者中，130 例（38.8%）被诊断为非严重肌少症，47 例（14.0%）为严重肌少症。82 例（24.5%）精神分裂症患者患有肺炎。研究显示，严重肌少症组肺炎发生率最高，其次为非严重肌少症组（严重肌少症组、非严重肌少症组和正常组的肺炎发生率分别为 38.3%、28.46%和 17.09%，p=0.005）。与正常组相比，非严重肌少症组（OR=1.93，95%CI：1.1-3.389）和严重肌少症组（OR=3.011，95%CI：1.467-6.183）患肺炎的风险更高。我们进一步调整了性别、吸烟史、慢性阻塞性肺疾病（COPD）、患者健康问卷（PHQ-9）评分和苯海索等潜在混杂因素，结果仅严重肌少症组患肺炎的风险增加（OR=2.366，95%CI：1.078-5.191）。
结论
本研究表明，稳定期精神分裂症患者中严重肌少症与肺炎有关。
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