Hariyadi Dewi Melani, Fitri Aldesra, Sudarma Sisunandar, Purwanti Tutiek, Erawati Tristiana
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
Department of Biology, Universitas Muhammadiyah, Purwokerto, Indonesia.
J Adv Pharm Technol Res. 2022 Jul-Sep;13(3):238-242. doi: 10.4103/japtr.japtr_99_22. Epub 2022 Jul 5.
Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%-2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity.
富含潜在脂肪酸成分的初榨椰子油（VCO）对药品和化妆品具有强大的抗菌作用。VCO被水解为水解初榨椰子油（HVCO）以增强其活性。本研究旨在优化VCO和HVCO微球。检测项目包括脂肪酸含量、密度和感官特性。通过产率、水分含量（MC）、形态和尺寸对VCO和HVCO微球进行表征。脂肪酸含量通过气相色谱 - 质谱法测定，而对于微球，研究了海藻酸钠浓度（1% - 2%）和聚乙二醇（PEG）添加量的影响。VCO和HVCO微球配方表明，聚合物浓度增加，产率提高，MC改善。添加PEG的最适宜2%海藻酸钠使产率提高至59%并减小了尺寸。F4微球产率最高，MC低且脂肪酸含量高。形态呈球形且光滑，尺寸小。HVCO微球的优化显示出其在抗菌和抗真菌活性方面的潜力。
