Zhang Taohong, Wang Lisha, He Xinyi, Lu Hailin, Gao Li
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China.
College of Mechanical and Electronic Engineering, Xi'an Polytechnic University, Xi'an, China.
Front Med (Lausanne). 2022 Jul 22;9:799145. doi: 10.3389/fmed.2022.799145. eCollection 2022.
Nanoparticles that contact human cells without damaging basic human tissues are becoming more widely used in medicine. Efficient delivery to the intracellular target cell or compartment through the cell membrane must be achieved with minimal cytotoxicity to healthy cells. FeO nanoparticles have been widely used in biomedical research for their magnetic, non-toxic, and biocompatible properties. However, the effects of FeO nanoparticles coated with chitosan (CS) on gynecological cells are unclear. In this study, the FeO nanoparticles were coated with CS to enhance their cytocompatibility and dispersion in water. These CS-FeO nanoparticles were taken up by gynecological cells and did not affect cell viability . They have greater cytocompatibility in acidic environments than normal FeO nanoparticles and have the potential for drug delivery into gynecological cells.
能够接触人体细胞而不损害人体基本组织的纳米颗粒在医学领域的应用越来越广泛。必须以对健康细胞的细胞毒性最小的方式实现通过细胞膜高效递送至细胞内靶细胞或区室。FeO纳米颗粒因其磁性、无毒和生物相容性等特性而在生物医学研究中得到广泛应用。然而，壳聚糖（CS）包覆的FeO纳米颗粒对妇科细胞的影响尚不清楚。在本研究中，对FeO纳米颗粒进行了CS包覆，以增强其细胞相容性和在水中的分散性。这些CS-FeO纳米颗粒被妇科细胞摄取且不影响细胞活力。它们在酸性环境中比普通FeO纳米颗粒具有更强的细胞相容性，并且具有向妇科细胞递送药物的潜力。
