Cytocompatibility of pH-sensitive, chitosan-coated FeO nanoparticles in gynecological cells.

Nanoparticles that contact human cells without damaging basic human tissues are becoming more widely used in medicine. Efficient delivery to the intracellular target cell or compartment through the cell membrane must be achieved with minimal cytotoxicity to healthy cells. FeO nanoparticles have been widely used in biomedical research for their magnetic, non-toxic, and biocompatible properties. However, the effects of FeO nanoparticles coated with chitosan (CS) on gynecological cells are unclear. In this study, the FeO nanoparticles were coated with CS to enhance their cytocompatibility and dispersion in water. These CS-FeO nanoparticles were taken up by gynecological cells and did not affect cell viability . They have greater cytocompatibility in acidic environments than normal FeO nanoparticles and have the potential for drug delivery into gynecological cells.