Chen Yuhao, Tang Yuying, Li Yuanbo, Rui Yukui, Zhang Peng
Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100093, China.
Tangshan Jinhai New Material Co., Ltd., Tangshan 063000, China.
Nanomaterials (Basel). 2024 Oct 3;14(19):1598. doi: 10.3390/nano14191598.
This article explores the emerging field of nanomedicine as a drug delivery system, aimed at enhancing the therapeutic efficacy of active pharmaceutical ingredients in medicinal plants. The traditional methods of applying medicinal plants present several limitations, such as low bioavailability, poor solubility, challenges in accurately controlling drug dosage, and inadequate targeting. Nanoformulations represent an innovative approach in drug preparation that employs nanotechnology to produce nanoscale particles or carriers, which are designed to overcome these limitations. Nanoformulations offer distinct advantages, significantly enhancing the solubility and bioavailability of drugs, particularly for the poorly soluble components of medicinal plants. These formulations effectively enhance solubility, thereby facilitating better absorption and utilization by the human body, which in turn improves drug efficacy. Furthermore, nanomedicine enables targeted drug delivery, ensuring precise administration to the lesion site and minimizing side effects on healthy tissues. Additionally, nanoformulations can regulate drug release rates, extend the duration of therapeutic action, and enhance the stability of treatment effects. However, nanoformulations present certain limitations and potential risks; their stability and safety require further investigation, particularly regarding the potential toxicity with long-term use. Nevertheless, nanomaterials demonstrate substantial potential in augmenting the efficacy of active pharmaceutical ingredients in medicinal plants, offering novel approaches and methodologies for their development and application.
本文探讨了作为药物递送系统的纳米医学这一新兴领域，旨在提高药用植物中活性药物成分的治疗效果。应用药用植物的传统方法存在一些局限性，如生物利用度低、溶解度差、精确控制药物剂量存在挑战以及靶向性不足。纳米制剂是药物制备中的一种创新方法，它利用纳米技术生产纳米级颗粒或载体，旨在克服这些局限性。纳米制剂具有明显优势，能显著提高药物的溶解度和生物利用度，特别是对于药用植物中难溶性成分。这些制剂有效提高溶解度，从而促进人体更好地吸收和利用，进而提高药物疗效。此外，纳米医学能够实现靶向给药，确保精确施用于病变部位并最大限度减少对健康组织的副作用。另外，纳米制剂可以调节药物释放速率，延长治疗作用持续时间，并增强治疗效果的稳定性。然而，纳米制剂存在一定的局限性和潜在风险；它们的稳定性和安全性需要进一步研究，特别是长期使用的潜在毒性。尽管如此，纳米材料在增强药用植物中活性药物成分的疗效方面具有巨大潜力，为其开发和应用提供了新的途径和方法。
