病例报告：接种新型冠状病毒灭活疫苗（BBIBP-CorV）后发生亚急性甲状腺炎。
Case Report: Subacute thyroiditis after receiving inactivated SARS-CoV-2 vaccine (BBIBP-CorV).
作者信息
Pi Linhua, Lin Jian, Zheng Ying, Wang Zhen, Zhou Zhiguang
机构信息
Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Changsha, China.
出版信息
Front Med (Lausanne). 2022 Jul 22;9:918721. doi: 10.3389/fmed.2022.918721. eCollection 2022.
BACKGROUND
Subacute thyroiditis, an inflammatory disease, has been reported caused by vaccines in rare cases. In the context of the coronavirus disease 19 pandemic, various SARS-CoV-2 vaccines have been developed and may be potential triggers for subacute thyroiditis.
CASE PRESENTATION
We report a case of subacute thyroiditis 3 days after receiving the second dose of inactivated SARS-CoV-2 vaccine (BBIBP-CorV). The patient did not report a previous history of thyroid disease, upper respiratory tract infection, or COVID-19. Physical examination, laboratory testing, ultrasonography, and radioactive iodine uptake were consistent with subacute thyroiditis. During follow-up, the patient recovered from symptoms and signs, and imaging changes except for hypothyroidism, requiring an ongoing thyroxine replacement.
CONCLUSIONS
Inactivated SARS-CoV-2 vaccine may be a causal trigger leading to subacute thyroiditis. Clinicians should be aware of subacute thyroiditis as a possible thyroid-related side effect of an inactivated SARS-CoV-2 vaccine.
背景
亚急性甲状腺炎是一种炎症性疾病，罕见情况下有疫苗引发该病的报道。在新型冠状病毒肺炎大流行的背景下，多种严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗已研发出来，可能是亚急性甲状腺炎的潜在诱发因素。
病例报告
我们报告1例在接种第二剂灭活SARS-CoV-2疫苗（BBIBP-CorV）3天后发生亚急性甲状腺炎的病例。患者既往无甲状腺疾病、上呼吸道感染或新型冠状病毒肺炎病史。体格检查、实验室检查、超声检查及放射性碘摄取检查结果均符合亚急性甲状腺炎。随访期间，患者症状和体征消失，除甲状腺功能减退外影像学改变恢复，需持续进行甲状腺素替代治疗。
结论
灭活SARS-CoV-2疫苗可能是导致亚急性甲状腺炎的病因。临床医生应意识到亚急性甲状腺炎可能是灭活SARS-CoV-2疫苗引起的一种甲状腺相关副作用。
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