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胰岛素依赖型糖尿病中的甲状腺激素和甲状腺球蛋白自身抗体

Thyroid hormones and thyroglobulin autoantibodies in insulin dependent diabetes mellitus.

作者信息

Ilyés I, Tóth T, Kirilina S

出版信息

Acta Paediatr Hung. 1986;27(4):317-21.

PMID:3593581
Abstract

Serum T4, FT4, T3, and TSH were measured in a group of children with insulin dependent diabetes mellitus and a control group. In the insulin dependent diabetes mellitus group, serum T3 concentration was significantly lower than the control values. Serum T4, FT4 and TSH level did not differ. The difference in serum T3 concentration was significant between diabetic children with good or poor control. Thyroglobulin antibodies were investigated in diabetic children by Serono's "hTg antibodies" kit. Thyroglobulin antibodies were present in 14.5%. TSH concentration did not differ in antibody positive and negative cases, but one child with diabetes had evidence of moderately impaired thyroid reserve.

摘要

对一组胰岛素依赖型糖尿病儿童和一个对照组测定了血清总甲状腺素(T4)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(T3)和促甲状腺激素(TSH)。在胰岛素依赖型糖尿病组中,血清T3浓度显著低于对照值。血清T4、FT4和TSH水平无差异。血糖控制良好或不佳的糖尿病儿童之间血清T3浓度差异显著。采用赛诺菲公司的“hTg抗体”试剂盒对糖尿病儿童进行甲状腺球蛋白抗体检测。14.5%的糖尿病儿童存在甲状腺球蛋白抗体。抗体阳性和阴性病例的TSH浓度无差异,但有一名糖尿病儿童有甲状腺储备中度受损的证据。

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