Chen Liwen, Zhang Hui, Shang Chao, Hong Yang
Department of Neurobiology, School of Life Sciences, China Medical University, Shenyang, Liaoning, China.
Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
CNS Neurosci Ther. 2024 Dec;30(12):e70121. doi: 10.1111/cns.70121.
Mitochondria, known as the "energy factory" of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid proliferation, invasion, and drug resistance. Glioma, the most common brain tumor with a high recurrence rate and limited treatment options, has been linked to changes in mitochondrial structure and function. This review focuses on the bioenergetics, dynamics, metastasis, and autophagy of mitochondria in relation to glioma proliferation, as well as the potential use of mitochondria-targeting drugs in glioma treatment.
线粒体，被誉为细胞的“能量工厂”，是大多数真核细胞中具有双层膜结构和遗传物质的重要细胞器。它们在肿瘤发生和发展中起着关键作用，肿瘤细胞中线粒体结构和功能的改变会导致快速增殖、侵袭和耐药等特征。胶质瘤是最常见的脑肿瘤，复发率高且治疗选择有限，其与线粒体结构和功能的变化有关。本文综述了线粒体的生物能量学、动力学、转移和自噬与胶质瘤增殖的关系，以及线粒体靶向药物在胶质瘤治疗中的潜在应用。
