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薰衣草精油及其萜类成分对胶质母细胞瘤细胞模型中的肿瘤特性有负面影响。

Lavender Essential Oil and Its Terpenic Components Negatively Affect Tumor Properties in a Cell Model of Glioblastoma.

作者信息

Russo Miriam, Martella Noemi, Gargano Deborah, Fantasma Francesca, Marcovecchio Chiara, Russo Veronica, Oliva Maria Antonietta, Segatto Marco, Saviano Gabriella, Di Bartolomeo Sabrina, Arcella Antonietta

机构信息

Department of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.

IRCCS Istituto Neurologico Mediterraneo NEUROMED, Via Atinense 18, 86077 Pozzilli, Italy.

出版信息

Molecules. 2024 Dec 22;29(24):6044. doi: 10.3390/molecules29246044.

DOI:10.3390/molecules29246044
PMID:39770132
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676467/
Abstract

Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults, characterized by extensive growth, a high recurrence rate, and resistance to treatment. Growing research interest is focusing on the biological roles of natural compounds due to their potential beneficial effects on health. Our research aimed to investigate the effects of lavender essential oil (LEO) on a GBM cell model. Chemical characterization using GC-MS analysis indicated that LEO contains several terpenes, compounds that have been found to exhibit anticancer properties by interfering with key cancer-related pathways in several cancer models. By means of cell biology assays, we demonstrated that LEO impairs cell proliferation and migration, and also reduces oxidative stress in U87 cells. We further observed that Terpinen-4-ol, contained in LEO, was capable of reproducing the effects of the oil on GBM cells. Our results suggest that the terpenic molecules present in LEO could be considered valuable allies alongside conventional therapies against GBM.

摘要

胶质母细胞瘤（GBM）是成人中最常见且侵袭性最强的脑癌形式，其特征为广泛生长、高复发率以及对治疗产生耐药性。由于天然化合物对健康具有潜在益处，因此越来越多的研究兴趣集中在它们的生物学作用上。我们的研究旨在探讨薰衣草精油（LEO）对GBM细胞模型的影响。使用气相色谱 - 质谱联用（GC-MS）分析进行的化学表征表明，LEO含有几种萜类化合物，这些化合物已被发现在多种癌症模型中通过干扰关键的癌症相关途径而表现出抗癌特性。通过细胞生物学实验，我们证明LEO会损害U87细胞的增殖和迁移，并降低其氧化应激。我们进一步观察到，LEO中含有的萜品烯 - 4 - 醇能够重现该精油对GBM细胞的作用。我们的结果表明，LEO中存在的萜类分子可被视为与针对GBM的传统疗法并肩作战的宝贵盟友。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/f6472b0a8f60/molecules-29-06044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/fb94a7ac90e4/molecules-29-06044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/32c23d54f5fc/molecules-29-06044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/e03ccd0c0e96/molecules-29-06044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/8c06702eb6b2/molecules-29-06044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/4659650492e7/molecules-29-06044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/c735aa456fc2/molecules-29-06044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/f6472b0a8f60/molecules-29-06044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/fb94a7ac90e4/molecules-29-06044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/32c23d54f5fc/molecules-29-06044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/e03ccd0c0e96/molecules-29-06044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/8c06702eb6b2/molecules-29-06044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/4659650492e7/molecules-29-06044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/c735aa456fc2/molecules-29-06044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb04/11676467/f6472b0a8f60/molecules-29-06044-g007.jpg

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