Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, China.
Orthopedic Biomedical Materials Engineering Laboratory of Hunan Province, Changsha, China.
Front Immunol. 2022 Jul 22;13:916915. doi: 10.3389/fimmu.2022.916915. eCollection 2022.
Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B/C and gene clusters A/B/C. Then, a close relationship between ICI and gene clusters was established. We found that the features of these clusters were consistent with the characteristics of immune-inflamed tumors (cluster C), immune-desert tumors (cluster B), and immune-excluded tumors (cluster A). Moreover, cluster C was sensitive to immunotherapy. Finally, an independent ICI score was established to predict the therapeutic effect, which has prospects for application in guiding immunotherapy during clinical practice.
黏液纤维肉瘤（MFS）是一种高度恶性的软组织肉瘤亚型，占病例的 5%。据报道，免疫细胞浸润（ICI）指导的免疫疗法是一种很有前途的治疗策略。在这里，来自两个独立数据库的 MFS 样本（n=104）被分类为 ICI 簇 A/B/C 和基因簇 A/B/C。然后，建立了 ICI 与基因簇之间的密切关系。我们发现，这些簇的特征与免疫浸润肿瘤（簇 C）、免疫荒漠肿瘤（簇 B）和免疫排除肿瘤（簇 A）的特征一致。此外，簇 C 对免疫治疗敏感。最后，建立了一个独立的 ICI 评分来预测治疗效果，该评分有望在指导临床实践中的免疫治疗方面得到应用。
Zotero 插件
