H Baky Mostafa, Fahmy Heba, Farag Mohamed A
Pharmacognosy Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt.
Pharmacognosy Department, Faculty of Pharmacy, Modern University for Technology & Information, Cairo 11835, Egypt.
ACS Omega. 2022 Jul 19;7(30):25948-25957. doi: 10.1021/acsomega.2c02838. eCollection 2022 Aug 2.
(Gaertn.) Desr. (known as Malabar tamarind) is a popular traditional herbal medicine and is one of the well-known folk medicines reported for the treatment of obesity and incorporated in several nutraceuticals worldwide. These effects are mediated by a myriad of bioactive compounds with most effects attributed to its hydroxy citric acid (HCA) content. This review aims to present a holistic overview on novel trends in the production of . bioactive components and how extraction optimization is important to ensure best product quality with its reported nanoformulations with particular emphasis on HCA content. Further, an overview of the different analytical approaches used for quality control assessment of . plant and its nutraceuticals is presented highlighting both advantages and limitations. Moreover, analytical approaches for detecting . metabolites in biological fluids with emphasis on HCA level to determine its pharmacokinetics and proof of efficacy are presented for the first time.
（Gaertn.）Desr.（俗称马拉巴尔罗望子）是一种广受欢迎的传统草药，是治疗肥胖症的著名民间药物之一，并被纳入全球多种营养保健品中。这些作用是由多种生物活性化合物介导的，大多数作用归因于其羟基柠檬酸（HCA）含量。本综述旨在全面概述生物活性成分生产的新趋势，以及提取优化对于确保其纳米制剂（特别强调HCA含量）的最佳产品质量为何重要。此外，还介绍了用于该植物及其营养保健品质量控制评估的不同分析方法的概述，突出了其优点和局限性。此外，首次介绍了用于检测生物流体中代谢物的分析方法，重点是HCA水平，以确定其药代动力学和疗效证据。
