Kacimi Salah Eddine O, Elgenidy Anas, Cheema Huzaifa Ahmad, Ould Setti Mounir, Khosla Atulya Aman, Benmelouka Amira Yasmine, Aloulou Mohammad, Djebabria Kawthar, Shamseldin Laila Salah, Riffi Omar, Mesli Nabil Smain, Sekkal Hanane Z, Afifi Ahmed M, Shah Jaffer, Ghozy Sherief
Faculty of Medicine, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, Algeria.
Faculty of Medicine, Cairo University, Cairo, Egypt.
Front Oncol. 2022 Jul 20;12:925596. doi: 10.3389/fonc.2022.925596. eCollection 2022.
Exposure to recurrent infections in childhood was linked to an increased risk of cancer in adulthood. There is also evidence that a history of tonsillectomy, a procedure often performed in children with recurrent infections, is linked to an increased risk of leukemia and Hodgkin lymphoma. Tonsillectomy could be directly associated with cancer risk, or it could be a proxy for another risk factor such as recurrent infections and chronic inflammation. Nevertheless, the role of recurrent childhood infections and tonsillectomy on the one hand, and the risk of breast cancer (BC) in adulthood remain understudied. Our study aims to verify whether a history of tonsillectomy increases the risk of BC in women.
A systematic review was performed using PubMed, Google Scholar, Scopus, Embase, and Web of Science databases from inception to January 25, 2022, to identify the studies which assessed the association between the history of tonsillectomy and BC in females. Odds ratio (OR) was calculated using the random/fixed-effects models to synthesize the associations between tonsillectomy and BC risk based on heterogeneity.
Eight studies included 2252 patients with breast cancer of which 1151 underwent tonsillectomy and 5314 controls of which 1725 had their tonsils removed. Patients with a history of tonsillectomy showed a higher subsequent risk of developing BC (OR, 1.24; 95% CI: 1.11-1.39) as compared to patients without a history of tonsillectomy. Influence analyses showed that no single study had a significant effect on the overall estimate or the heterogeneity.
Our study revealed that a history of tonsillectomy is associated with an increased risk of breast cancer. These findings underscore the need for frequent follow-ups and screening of tonsillectomy patients to assess for the risk of BC.
儿童时期反复感染与成年后患癌风险增加有关。也有证据表明，扁桃体切除术（一种常在反复感染的儿童中进行的手术）史与白血病和霍奇金淋巴瘤风险增加有关。扁桃体切除术可能直接与癌症风险相关，也可能是另一个风险因素（如反复感染和慢性炎症）的替代指标。然而，儿童时期反复感染和扁桃体切除术一方面与成年后患乳腺癌（BC）风险之间的关系仍未得到充分研究。我们的研究旨在验证扁桃体切除术史是否会增加女性患BC的风险。
使用PubMed、谷歌学术、Scopus、Embase和科学网数据库进行系统综述，检索从数据库建立至2022年1月25日评估扁桃体切除术史与女性BC之间关联的研究。基于异质性，使用随机/固定效应模型计算比值比（OR），以综合扁桃体切除术与BC风险之间的关联。
八项研究纳入了2252例乳腺癌患者，其中1151例接受了扁桃体切除术，5314例对照者中1725例切除了扁桃体。与无扁桃体切除术史的患者相比，有扁桃体切除术史的患者随后患BC的风险更高（OR，1.24；95%CI：1.11 - 1.39）。影响分析表明，没有一项研究对总体估计或异质性有显著影响。
我们的研究表明，扁桃体切除术史与乳腺癌风险增加有关。这些发现强调了对扁桃体切除术患者进行频繁随访和筛查以评估BC风险的必要性。
