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自体骨移植和间充质细胞移植重建膝关节骨软骨缺损

Knee Osteochondral Defect Reconstruction With Autologous Bone Grafting and Mesenchymal Cell Transplantation.

作者信息

Jancewicz Piotr, Mrozek Tomasz, Góralczyk Adrian, Radziwon Piotr, Rusak Małgorzata, Chociej-Stypułkowska Joanna, Hermanowicz Krzysztof

机构信息

ORTIM Orthopaedic Clinic, Bialystok, Poland.

Department of Orthopedics and Traumatology, Hospital of Ministry of Internal Affairs and Administration, Białystok, Poland.

出版信息

Arthrosc Tech. 2022 Jun 8;11(7):e1157-e1162. doi: 10.1016/j.eats.2022.02.025. eCollection 2022 Jul.

DOI:10.1016/j.eats.2022.02.025
PMID:35936864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9353078/
Abstract

Osteochondral defects of the knee are common in orthopaedic patients. They are challenging to treat, especially in young, highly demanding patients who do not qualify for arthroplasty. Among the many possibilities to treat osteochondral lesions presented so far, none is ideal. Because of the poor healing potential of cartilage, treatment outcomes significantly worsen with larger lesions. The treatment of large defects usually requires expensive solutions, sometimes including second-stage surgery. Using mesenchymal stem cell transplantation and cancellous bone autografts, the technique presented here for osteochondral lesion reconstruction can be effectively used to treat large osteochondral lesions in a single-stage procedure.

摘要

膝关节骨软骨缺损在骨科患者中很常见。它们的治疗具有挑战性，尤其是对于不符合关节置换术条件的年轻、要求较高的患者。在目前提出的治疗骨软骨损伤的众多方法中，没有一种是理想的。由于软骨愈合潜力差，较大的损伤会使治疗效果明显恶化。大缺损的治疗通常需要昂贵的解决方案，有时还包括二期手术。使用间充质干细胞移植和松质骨自体移植，本文介绍的骨软骨损伤重建技术可有效地用于单阶段治疗大的骨软骨损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/bf66bae5744f/gr12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/bf66bae5744f/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/8a5ad436f97a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/ab02c46bc7c5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/96f4710401e1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/dfb2bbb7b46a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/ed8240b76b88/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/afa46fafde08/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/c33aea8278f8/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/d1c93ba014a3/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/f5c29478120a/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/77d9a64eee40/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/422fa1e39e8b/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a27/9353078/bf66bae5744f/gr12.jpg

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本文引用的文献

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Arthrosc Tech. 2021 Feb 8;10(3):e751-e756. doi: 10.1016/j.eats.2020.10.065. eCollection 2021 Mar.
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Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate.关节镜下使用细胞外基质支架和骨髓抽吸浓缩物修复软骨缺损
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