Enteric Viruses Group, Indian Council of Medical Research (ICMR)-National Institute of Virology, Pune, India.
Bacteriology Group, Indian Council of Medical Research (ICMR)-National Institute of Virology, Pune, India.
Front Public Health. 2022 Jul 22;10:897662. doi: 10.3389/fpubh.2022.897662. eCollection 2022.
There have been several reports across the globe regarding the presentation of a severe multi-system hyperinflammatory syndrome, resembling Kawasaki disease (KD), in the pediatric population during the SARS-CoV-2 pandemic. The exact pathophysiology is still unclear; however, children typically demonstrate multi-organ dysfunction and less respiratory system involvement compared to adults. The limited literature is available at present for the identification and management of such patients. In this study, we investigated four cases in children ages 11-15 years that fulfilled the case definition for the pediatric multi-system inflammatory syndrome. All were found negative for SARS-CoV-2 from oropharyngeal swabs and stool. As they were having symptoms of diarrhea, tests for bacterial and enteric viral infections were performed after SARS-CoV-2 testing. Molecular analysis revealed that all the children were infected with enterovirus (Echovirus-18). Early and exact diagnosis is vital for timely, effective, and potentially life-saving management of such cases.
目前已有全球范围内的多项报告显示，在 SARS-CoV-2 大流行期间，儿科人群中出现了类似于川崎病 (KD) 的严重多系统炎症综合征。确切的病理生理学机制尚不清楚；然而，与成人相比，儿童通常表现为多器官功能障碍，呼吸系统受累较少。目前针对此类患者的识别和管理的相关文献有限。在这项研究中，我们调查了年龄在 11-15 岁之间的符合儿科多系统炎症综合征病例定义的 4 例患儿。所有患儿的口咽拭子和粪便均未检测到 SARS-CoV-2 呈阳性。由于他们有腹泻症状，在检测 SARS-CoV-2 后进行了细菌和肠道病毒感染的检测。分子分析显示，所有患儿均感染了肠道病毒（Echovirus-18）。早期、准确的诊断对于此类病例的及时、有效和潜在的救命治疗至关重要。
