Department of Radiology, Wuhan Pulmonary Hospital, Wuhan, 430000 Hubei Province, China.
Biomed Res Int. 2022 Jul 27;2022:4119912. doi: 10.1155/2022/4119912. eCollection 2022.
Lung cancer is a common clinical thoracic malignant tumor, which had a serious impact on the safety of patients, currently ranking first in all malignant tumors in morbidity and mortality, with generally less than 5% survival rate in 5 years.
To investigate the relationship and significance between carcinoembryonic antigen (CEA) and precursor gastrin-releasing peptide (ProGRP) changing levels in bronchoalveolar lavage fluid (BALF) and CT imaging features in patients with peripheral lung cancer.
A total of 90 patients diagnosed with peripheral lung cancer as the lung cancer group and 60 patients with benign lung diseases as the control group in our hospital from May 2019 to October 2021 were selected to compare the differences of CEA and ProGRP in BALF by the classification of CT features.
The levels of CEA and ProGRP in the BALF of the lung cancer group were significantly higher than those of the control group; the proportion of patients with lobulation sign, burr sign, ground glass sign, pleural effusion, and lesion diameter ≥ 3.0 cm in the lung cancer group was higher than that in the control group; the CEA level in BALF of lung cancer patients with spicule sign, pleural effusion, and lesion diameter ≥ 3.0 cm was significantly higher than that without these symptoms, while ProGRP level in the BALF of lung cancer patients with lobulation sign, burr sign, ground glass sign, pleural effusion, and lesion diameter ≥ 3.0 cm was significantly higher than that of lung cancer patients without these symptoms.
The check of CEA and ProGRP in BALF in combination with CT features has a certain clinical value for the diagnosis of lung cancer. At the same time, the increased levels of CEA and ProGRP in BALF have a certain correlation with the changes of malignant signs of lung cancer in CT examination.
肺癌是一种常见的临床胸部恶性肿瘤，严重影响患者的安全，目前在发病率和死亡率方面均位居所有恶性肿瘤之首，5 年生存率一般不足 5%。
探讨支气管肺泡灌洗液（BALF）中癌胚抗原（CEA）和前胃泌素释放肽（ProGRP）水平变化与周围型肺癌 CT 影像学特征的关系及其意义。
选取 2019 年 5 月至 2021 年 10 月在我院诊治的 90 例周围型肺癌患者作为肺癌组，同期 60 例良性肺部疾病患者作为对照组，比较 CT 特征分类下 BALF 中 CEA 和 ProGRP 的差异。
肺癌组 BALF 中 CEA 和 ProGRP 水平明显高于对照组；肺癌组分叶征、毛刺征、磨玻璃征、胸腔积液、病灶直径≥3.0cm 患者比例高于对照组；肺癌组有棘突征、胸腔积液、病灶直径≥3.0cm 患者 BALF 中 CEA 水平明显高于无这些症状者，而肺癌组有分叶征、毛刺征、磨玻璃征、胸腔积液、病灶直径≥3.0cm 患者 BALF 中 ProGRP 水平明显高于无这些症状者。
结合 CT 特征检查 BALF 中 CEA 和 ProGRP 对肺癌诊断具有一定的临床价值，同时 BALF 中 CEA 和 ProGRP 水平升高与 CT 检查中肺癌恶性征象变化具有一定相关性。
