Vassilopoulou Emilia, Bumbacea Roxana Silvia, Pappa Aikaterini Konstantina, Papadopoulos Athanasios N, Bumbacea Dragos
Department of Nutritional Sciences and Dietetics, International Hellenic University, Thessaloniki, Greece.
Allergy Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Front Nutr. 2022 Jul 22;9:931313. doi: 10.3389/fnut.2022.931313. eCollection 2022.
The critical role played by the nutritional status in the complications, duration of hospitalization and mortality in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) has emerged from several research studies in diverse populations. Obesity has been associated with an increased risk of serious complications, as the adipose tissue appears to have significant effects on the immune response. The aim of this narrative review was to investigate the relationship between COVID-19 and obesity.
We performed a review of papers in the English language derived from PubMed, Science Direct, and Web of Science. The primary outcomes investigated were the severity of the disease, admission to the intensive care unit (ICU), need for intubation, and mortality.
Review of 44 eligible studies from 18 countries around the world revealed evidence that obesity increases the risk of severe COVID-19 complications, ICU admission, intubation and mortality. Patients with a higher body mass index (BMI) appear to be more vulnerable to SARS-CoV-2 infection, with more severe illness requiring admission to ICU and intubation, and to have higher mortality. A healthy body weight should be targeted as a long-term prevention measure against acute complications of infection, and in the event of COVID-19, overweight and obese patients should be monitored closely.
多项针对不同人群的研究表明，营养状况在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染（COVID-19）的并发症、住院时间和死亡率方面起着关键作用。肥胖与严重并发症风险增加有关，因为脂肪组织似乎对免疫反应有显著影响。本叙述性综述的目的是研究COVID-19与肥胖之间的关系。
我们对来自PubMed、Science Direct和Web of Science的英文论文进行了综述。研究的主要结果包括疾病的严重程度、入住重症监护病房（ICU）、插管需求和死亡率。
对来自世界18个国家的44项符合条件的研究进行综述发现，有证据表明肥胖会增加COVID-19严重并发症、入住ICU、插管和死亡的风险。体重指数（BMI）较高的患者似乎更容易感染SARS-CoV-2，病情更严重，需要入住ICU并进行插管，且死亡率更高。应将保持健康体重作为预防感染急性并发症的长期措施，对于COVID-19患者，超重和肥胖患者应密切监测。
