Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Chaum Life Center, CHA University, Seoul 06062, Republic of Korea.
Int J Mol Sci. 2023 Aug 6;24(15):12505. doi: 10.3390/ijms241512505.
This study aimed to investigate whether body fat and muscle percentages are associated with natural killer cell activity (NKA). This was a cross-sectional study, conducted on 8058 subjects in a medical center in Korea. The association between the muscle and fat percentage tertiles and a low NKA, defined as an interferon-gamma level lower than 500 pg/mL, was assessed. In both men and women, the muscle mass and muscle percentage were significantly low in participants with a low NKA, whereas the fat percentage, white blood cell count, and C-reactive protein (CRP) level were significantly high in those with a low NKA. Compared with the lowest muscle percentage tertile as a reference, the fully adjusted odd ratios (ORs) (95% confidence intervals (CIs)) for a low NKA were significantly lower in T2 (OR: 0.69; 95% CI: 0.55-0.86) and T3 (OR: 0.74; 95% CI: 0.57-0.95) of men, and T3 (OR: 0.76; 95% CI: 0.59-0.99) of women. Compared with the lowest fat percentage tertile as a reference, the fully adjusted OR was significantly higher in T3 of men (OR: 1.31; 95% CI: 1.01-1.69). A high muscle percentage was significantly inversely associated with a low NKA in men and women, whereas a high fat percentage was significantly associated with a low NKA in men.
本研究旨在探讨体脂肪率和肌肉百分比是否与自然杀伤细胞活性（NKA）有关。这是一项横断面研究，在韩国一家医学中心对 8058 名受试者进行了研究。评估了肌肉和脂肪百分比三分位数与低 NKA（干扰素-γ水平低于 500pg/ml）之间的关系。在男性和女性中，低 NKA 组的肌肉质量和肌肉百分比明显较低，而低 NKA 组的脂肪百分比、白细胞计数和 C 反应蛋白（CRP）水平明显较高。与最低肌肉百分比三分位组作为参考相比，男性 T2（OR：0.69；95%置信区间（CI）：0.55-0.86）和 T3（OR：0.74；95% CI：0.57-0.95）三分位组和女性 T3（OR：0.76；95% CI：0.59-0.99）的低 NKA 的完全调整比值比（OR）明显降低。与最低脂肪百分比三分位组作为参考相比，男性 T3 三分位组的完全调整 OR 明显较高（OR：1.31；95% CI：1.01-1.69）。高肌肉百分比与男性和女性的低 NKA 显著呈负相关，而高脂肪百分比与男性的低 NKA 显著相关。
