Aronica Eleonora, Binder Devin K, Drexel Meinrad, Ikonomidou Chrysanthy, Kadam Shilpa D, Sperk Guenther, Steinhäuser Christian
Amsterdam UMC, University of Amsterdam, Department of (Neuro) Pathology, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands.
Epilepsia Open. 2022 Aug 8. doi: 10.1002/epi4.12638.
The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. This article addresses neuropathological changes associated with seizures and epilepsy in rodent models of epilepsy. We discuss CDEs for histopathological parameters for neurodegeneration, changes in astrocyte morphology and function, mechanisms of inflammation, and changes in the blood-brain barrier and myelin/oligodendrocytes resulting from recurrent seizures in rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the rationale and methodological aspects of individual neuropathological examinations. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of rational therapy concepts for treating epilepsies, seizures, and comorbidities and the development of biomarkers assessing the pathological state of the disease.
国际抗癫痫联盟/美国癫痫协会（ILAE/AES）联合转化任务组发起了TASK3工作组，以创建临床前癫痫研究各方面的通用数据元素（CDE），这有助于提高实验设计的标准化。本文探讨了癫痫啮齿动物模型中与癫痫发作和癫痫相关的神经病理学变化。我们讨论了大鼠和小鼠反复癫痫发作导致的神经退行性变的组织病理学参数、星形胶质细胞形态和功能变化、炎症机制以及血脑屏障和髓鞘/少突胶质细胞变化方面的CDE。我们提供了详细的CDE表格和病例报告表（CRF），并在这篇配套稿件中讨论了个体神经病理学检查的基本原理和方法学方面。所有研究人员均可使用这些CDE、CRF和配套论文，它们的使用将有利于转化临床前癫痫研究的协调和可比性。最终希望是促进针对癫痫、癫痫发作和合并症的合理治疗概念的发展以及评估疾病病理状态的生物标志物的开发。
