Shen Jie, Gao You-Ling, Lu Ge, Chen Li, Cheng Jie, Xia You-Bing
School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
School of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; Department of Acupuncture and Moxibustion, Yangzhou Hospital of TCM.
Zhongguo Zhen Jiu. 2022 Aug 12;42(8):879-83. doi: 10.13703/j.0255-2930.20210901-k0002.
To explore the effect of electroacupuncture on endometrial receptivity and the pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET) in the patients with diminished ovarian reserve (DOR).
Sixty-eight patients of DOR undertaken IVF-ET were randomized into an observation group (34 cases, 2 cases dropped off) and a control group (34 cases, 1 case dropped off). In the control group, endometrial preparation was performed according to the routine protocol. In the observation group, on the base of the treatment as the control group, acupuncture was applied to Geshu (BL 17), Shenshu (BL 23), Mingmen (GV 4), Shiqizhui (EX-B 8), Ciliao (BL 32), Zhongliao (BL 33), Tianshu (ST 25), Qihai (CV 6) and Guanyuan (CV 4), etc. Electric stimulation was given at Ciliao (BL 32)-Zhongliao(BL 33), Tianshu (ST 25)-Zigong (EX-CA 1), with disperse-dense wave, 2 Hz/15 Hz in frequency and tolerable current in intensity. Electroacupuncture was given once every two days, 3 times weekly, lasing 3 menstrual cycles till 1 day before embryo transfer. The endometrial thickness and morphology were observed on the day of human chorionic gonadotropin (HCG) of egg retrieval cycle, the day of endometrial transformation in frozen-thawed embryo transfer (FET) cycle and the day of embryo transfer in both groups successively; as well as HCG positive rate, clinical pregnancy rate, embryo implantation rate and live birth rate.
In the observation group, the proportion of type A endometrium on the embryo transfer day was higher than those on HCG day of the egg retrieval cycle and the endometrial transformation day of FET cycle (<0.05), and also higher than that of the control group (<0.01). In the observation group, HCG positive rate, clinical pregnancy rate, embryo implantation rate and live birth rate were 75.0% (24/32), 71.9% (23/32), 47.4% (27/57) and 56.3% (18/32) respectively, and all higher than 36.4% (12/33), 30.3% (10/33), 18.0% (11/61) and 15.2% (5/33) in the control group separately (<0.01).
Electroacupuncture improves the endometrial receptivity and IVF-ET pregnancy outcomes in the patients of diminished ovarian reserve.
探讨电针疗法对卵巢储备功能减退（DOR）患者子宫内膜容受性及体外受精-胚胎移植（IVF-ET）妊娠结局的影响。
将68例行IVF-ET的DOR患者随机分为观察组（34例，脱落2例）和对照组（34例，脱落1例）。对照组按照常规方案进行子宫内膜准备。观察组在对照组治疗的基础上，针刺膈俞（BL 17）、肾俞（BL 23）、命门（GV 4）、十七椎（EX-B 8）、次髎（BL 32）、中髎（BL 33）、天枢（ST 25）、气海（CV 6）、关元（CV 4）等穴位。在次髎（BL 32）-中髎（BL 33）、天枢（ST 25）-子宫（EX-CA 1）给予电刺激，采用疏密波，频率为2 Hz/15 Hz，强度以患者耐受为宜。电针治疗每2天1次，每周3次，连续治疗3个月经周期，至胚胎移植前1天。分别观察两组在取卵周期人绒毛膜促性腺激素（HCG）日、冻融胚胎移植（FET）周期子宫内膜转化日及胚胎移植日的子宫内膜厚度和形态；以及HCG阳性率、临床妊娠率、胚胎着床率和活产率。
观察组胚胎移植日A型子宫内膜比例高于取卵周期HCG日及FET周期子宫内膜转化日（<0.05），且高于对照组（<0.01）。观察组HCG阳性率、临床妊娠率、胚胎着床率和活产率分别为75.0%（24/32）、71.9%（23/32）、47.4%（27/57）和56.3%（18/32），均分别高于对照组的36.4%（12/33）、30.3%（10/33）、18.0%（11/61）和15.2%（5/33）（<0.01）。
电针疗法可改善卵巢储备功能减退患者的子宫内膜容受性及IVF-ET妊娠结局。
