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翼手目动物的血浆性类固醇结合

Plasma sex steroid binding in Chiroptera.

作者信息

Kwiecinski G G, Damassa D A, Gustafson A W, Armao M E

出版信息

Biol Reprod. 1987 Apr;36(3):628-35. doi: 10.1095/biolreprod36.3.628.

DOI:10.1095/biolreprod36.3.628
PMID:3593835
Abstract

Plasma steroid binding was examined in samples obtained from seven species of bats representing four different families. A specific sex steroid-binding protein (SBP) was identified by steady-state polyacrylamide gel electrophoresis in representatives of two families, the phyllostomids and the vespertilionids. In these species, as in primates, SBP not only exhibited high affinity for the androgens testosterone and dihydrotestosterone (DHT), but also for estradiol. A specific SBP was not identified in the tropical American vampire bat or in the two species of pteropodids examined. In all species examined, except for the vampire bat, a specific corticosteroid-binding globulin (CBG) was also identified. In addition to binding glucocorticoids, CBG in these species appeared to bind androgens as well.

摘要

对来自代表四个不同科的七种蝙蝠的样本进行了血浆类固醇结合检测。通过稳态聚丙烯酰胺凝胶电泳在叶口蝠科和蝙蝠科的两个科的代表中鉴定出一种特异性性类固醇结合蛋白(SBP)。在这些物种中,与灵长类动物一样,SBP不仅对雄激素睾酮和双氢睾酮(DHT)表现出高亲和力,而且对雌二醇也表现出高亲和力。在热带美洲吸血蝙蝠或所检测的两种狐蝠科物种中未鉴定出特异性SBP。在所检测的所有物种中,除了吸血蝙蝠外,还鉴定出一种特异性皮质类固醇结合球蛋白(CBG)。除了结合糖皮质激素外,这些物种中的CBG似乎也结合雄激素。

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