Schiller H S, Holm R A, Sackett G P
Am J Physiol. 1978 May;234(5):E489-93. doi: 10.1152/ajpendo.1978.234.5.E489.
We measured the corticosterone and dihydrotestosterone steroid binding capacities of corticosteroid-binding globulin (CBG) and sex steroid plasma binding protein (SBP) throughout pregnancy in seven Macaca nemestrina. The nSBP binding capacity rises significantly by 28 days of pregnancy, remains elevated through 56 days, tends to fall through midpregnancy, and then decreases dramatically to very low values 130-153 days after conception. In contrast, nCBG rises slightly (1.2-fold) in early pregnancy, is elevated in midpregnancy, but is similar to nonpregnant values during the last trimester of pregnancy. Our data indicate that factors controlling the plasma concentration of nCBG and nSBP are not identical. The results are in sharp contrast to those observed in human pregnancies in which both hSBP and hCBG are increased severalfold during pregnancy, including at term. Because the changes of nCBG and nSBP during pregnancy do not paralle the changes observed in human beings even though their steroid binding characteristics are similar, the M. nemestrina may serve as a valuable model for defining the physiologic function of SBP and CBG and the mechanism(s) controlling their concentrations in blood.
我们测定了7只豚尾猕猴整个孕期皮质类固醇结合球蛋白（CBG）和性类固醇血浆结合蛋白（SBP）的皮质酮和二氢睾酮类固醇结合能力。nSBP结合能力在怀孕28天时显著升高，在56天内一直保持升高，在孕期中期趋于下降，然后在受孕后130 - 153天急剧下降至非常低的值。相比之下，nCBG在怀孕早期略有升高（1.2倍），在孕期中期升高，但在孕期最后三个月与未怀孕时的值相似。我们的数据表明，控制nCBG和nSBP血浆浓度的因素并不相同。这些结果与人类孕期观察到的结果形成鲜明对比，在人类孕期，hSBP和hCBG在整个孕期，包括足月时，都会增加几倍。由于尽管nCBG和nSBP的类固醇结合特性相似，但它们在孕期的变化与人类观察到的变化并不平行，豚尾猕猴可能是定义SBP和CBG的生理功能以及控制它们在血液中浓度的机制的有价值模型。
