The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Department of Biochemistry and Molecular Biology, Shantou University Medical College, No. 22, Xinling Road, Shantou, 515041, Guangdong, China.
Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Institute of Oncologic Pathology, Shantou University Medical College, Shantou, 515041, Guangdong, China.
Amino Acids. 2022 Dec;54(12):1541-1552. doi: 10.1007/s00726-022-03193-x. Epub 2022 Aug 8.
The post-translational modifications (PTMs), which are crucial in the regulation of protein functions, have great potential as biomarkers of cancer status. Fascin (Fascin actin-bundling protein 1, FSCN1), a key protein in the formation of filopodia that is structurally based on actin filaments (F-actin), is significantly associated with tumor invasion and metastasis. Studies have revealed various regulatory mechanisms of human Fascin, including PTMs. Although a number of Fascin PTM sites have been identified, their exact functions and clinical significance are much less explored. This review explores studies on the functions of Fascin and briefly discusses the regulatory mechanisms of Fascin. Next, to review the role of Fascin PTMs in cell biology and their associations with metastatic disease, we discuss the advances in the characterization of Fascin PTMs, including phosphorylation, ubiquitination, sumoylation, and acetylation, and the main regulatory mechanisms are discussed. Fascin PTMs may be potential targets for therapy for metastatic disease.
翻译后修饰（PTM）在蛋白质功能调节中至关重要，作为癌症状态的生物标志物具有巨大潜力。Fascin（肌动蛋白成束蛋白1，FSCN1）是丝状伪足形成中的关键蛋白，其结构基于肌动蛋白丝（F-肌动蛋白），与肿瘤侵袭和转移显著相关。研究揭示了人类Fascin的多种调节机制，包括翻译后修饰。尽管已经鉴定出许多Fascin翻译后修饰位点，但其确切功能和临床意义的探索却少得多。本综述探讨了关于Fascin功能的研究，并简要讨论了Fascin的调节机制。接下来，为了综述Fascin翻译后修饰在细胞生物学中的作用及其与转移性疾病的关联，我们讨论了Fascin翻译后修饰特征的进展，包括磷酸化、泛素化、SUMO化和乙酰化，并讨论了主要调节机制。Fascin翻译后修饰可能是转移性疾病治疗的潜在靶点。
