Gorlina N K, Stonans I Ia, Cheredeev A N, Koval'chuk L V, Kosnikov V V
Biull Eksp Biol Med. 1987 Jun;103(6):725-7.
Possible participation of immune system cells in the differentiation of non-lymphoid tissues has been examined. Lymphocytes were tested on transformed fibroblasts of L mouse strain. The presence of lymphocytes in L cell culture enhanced their differentiation, assessed by morphological, proliferative and biophysical criteria. The induction of L-cell differentiation took place during contact and short-distant interaction both with mouse and human lymphocytes. The phenomenon had a stable character, as it was revealed in L cells separated from lymphocytes during passaging. The results obtained indicate real and potential abilities of the immune system to affect differentiation of proliferating non-lymphoid tissues.
免疫系统细胞在非淋巴组织分化过程中的可能参与情况已得到研究。对L小鼠品系的转化成纤维细胞进行了淋巴细胞检测。通过形态学、增殖和生物物理标准评估，L细胞培养物中淋巴细胞的存在增强了它们的分化。L细胞分化的诱导发生在与小鼠和人类淋巴细胞接触及短距离相互作用期间。该现象具有稳定性，因为在传代过程中从淋巴细胞中分离出的L细胞中也观察到了这一现象。所得结果表明免疫系统具有影响增殖性非淋巴组织分化的实际和潜在能力。
