Prabhakar Neha Sharma, Kumar Saurabh, Gupta Prince Kumar, Singh Krishna Nand
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
J Org Chem. 2022 Aug 19;87(16):11112-11120. doi: 10.1021/acs.joc.2c01353. Epub 2022 Aug 8.
A metal-free visible-light-induced trifluoromethylation of Bunte salts of α-bromoketones/alkyl bromide/benzyl bromides/functionalized allyl (Baylis-Hillman) bromides has been accomplished using Langlois' reagent in the presence of inexpensive eosin Y as a photocatalyst to form the privileged trifluoromethylthiolated synthons. The method is straightforward, operationally simple, and endowed with broad substrate scope and good functional group tolerance.
在廉价的曙红Y作为光催化剂存在的情况下，使用朗格卢瓦试剂实现了α-溴代酮/烷基溴/苄基溴/官能化烯丙基（贝利斯-希尔曼）溴的Bunte盐的无金属可见光诱导三氟甲基化反应，以形成具有优势的三氟甲硫基化合成子。该方法直接明了，操作简单，具有广泛的底物范围和良好的官能团耐受性。
