可见光诱导的Bunte盐的光催化三氟甲基化反应：便捷合成三氟甲硫基化合成子
Visible-Light-Induced Photocatalytic Trifluoromethylation of Bunte Salts: Easy Access to Trifluoromethylthiolated Synthons.
作者信息
Prabhakar Neha Sharma, Kumar Saurabh, Gupta Prince Kumar, Singh Krishna Nand
机构信息
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
出版信息
J Org Chem. 2022 Aug 19;87(16):11112-11120. doi: 10.1021/acs.joc.2c01353. Epub 2022 Aug 8.
A metal-free visible-light-induced trifluoromethylation of Bunte salts of α-bromoketones/alkyl bromide/benzyl bromides/functionalized allyl (Baylis-Hillman) bromides has been accomplished using Langlois' reagent in the presence of inexpensive eosin Y as a photocatalyst to form the privileged trifluoromethylthiolated synthons. The method is straightforward, operationally simple, and endowed with broad substrate scope and good functional group tolerance.
在廉价的曙红Y作为光催化剂存在的情况下，使用朗格卢瓦试剂实现了α-溴代酮/烷基溴/苄基溴/官能化烯丙基（贝利斯-希尔曼）溴的Bunte盐的无金属可见光诱导三氟甲基化反应，以形成具有优势的三氟甲硫基化合成子。该方法直接明了，操作简单，具有广泛的底物范围和良好的官能团耐受性。
Zotero 插件