Chen Xiaoli, Wu Ge
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
BMC Chem. 2025 Feb 22;19(1):51. doi: 10.1186/s13065-025-01426-0.
A successful methodology for the copper-catalyzed dehydrogenated methylsulfonylation of alkenes utilizing CHSSONa in conjunction with hypervalent iodine reagents was successfully established. This method offers a practical avenue to obtain allyl methyl sulfones and alkenyl methyl sulfones by forming C-S bonds. Using the C-H bond oxidation sulfonylation strategy with alkenes and Bunte salts, we successfully synthesized a total of twenty two compounds, including four examples of deuterium-substituted molecules, and demonstrated one example of a scale-up reaction.
成功建立了一种利用CHSSONa与高价碘试剂相结合实现铜催化烯烃脱氢甲基磺酰化的成功方法。该方法为通过形成C-S键获得烯丙基甲基砜和烯基甲基砜提供了一条实用途径。利用烯烃和邦特盐的C-H键氧化磺酰化策略，我们成功合成了总共22种化合物，包括4个氘取代分子的实例，并展示了一个放大反应的实例。
