法氏柠檬酸杆菌和阿洛单胞柠檬酸杆菌天然产生的β-内酰胺酶与 CTX-M 酶的免疫检测的交叉反应。
Cross-reaction of naturally-produced β-lactamases from Citrobacter farmeri and Citrobacter amalonaticus with immunological detection of CTX-M enzymes.
机构信息
Emerging Antibiotic Resistance, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Emerging Antibiotic Resistance, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland; Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland.
出版信息
Diagn Microbiol Infect Dis. 2022 Oct;104(2):115760. doi: 10.1016/j.diagmicrobio.2022.115760. Epub 2022 Jun 30.
The NG-Test CTX-M MULTI immunochromatographic assay has been developed to identify CTX-M-type β-lactamases in Enterobacterales, being the most widespread extended-spectrum β-lactamases. We showed here that the chromosomally-encoded ß-lactamases from Citrobacter farmeri and Citrobacter amalonaticus generated false-positive NG-Test CTX-M MULTI results, compromising the specificity of the test.
NG-Test CTX-M MULTI 免疫层析检测法已被开发用于鉴定肠杆菌科中的 CTX-M 型β-内酰胺酶，这是最广泛分布的超广谱β-内酰胺酶。我们在这里表明，柠檬酸杆菌和醋酸钙不动杆菌的染色体编码的β-内酰胺酶会产生假阳性的 NG-Test CTX-M MULTI 检测结果，从而影响检测的特异性。
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