College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Research Center of Yuze skin health, Shanghai Jahwa, Shanghai 200082, PR China.
Chem Phys Lipids. 2022 Sep;247:105228. doi: 10.1016/j.chemphyslip.2022.105228. Epub 2022 Aug 5.
Smoking has toxic effects on the skin and can damage it. However, few studies have focused on the lipid profile changes of facial skin surface lipids (SSL) by passive smoking.
A cross-sectional analytical study was conducted on middle-aged females volunteered from Henan, China to participate in the study. A total of 20 passive smoking females and 20 non-passive smoking females were recruited for this study. The components of skin surface lipids were measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF-MS). Multivariate data analysis and enrichment analysis were used to investigate the differences in facial SSL between passive and non-passive smoking females.
There were 1247 lipid entities identified in facial SSL between passive and non-passive smoking females. Significant differences in composition of facial SSL were observed between the two groups. After multivariate data analysis suggested, 28 significantly different lipids were identified and classified into four classes in SSL of the female cheeks. As well as 32 significantly different lipids were obtained in SSL of the female foreheads, which included three classes of lipids. Subsequent analysis revealed that the content of fatty acids (FA) in passive smoking females was significantly reduced and the content of glycerolipids (GL) and sphingolipids (SP) increased, compared with the control group.
These results indicated that an increase in GLs and SPs of facial lipids and a decrease in FAs in passive smoking females. These changes in lipids might be associated with oxidative stress and interference with signaling pathways by substances in smoke. And passive smoking affected facial SSL and changed the content and metabolism of skin lipids.
吸烟对皮肤有毒性作用，会损害皮肤。然而，很少有研究关注被动吸烟对面部皮肤表面脂质（SSL）的脂质谱变化。
本研究采用横断面分析方法，从中国河南自愿参加研究的中年女性中招募了 20 名被动吸烟女性和 20 名非被动吸烟女性。采用超高效液相色谱四极杆飞行时间质谱（UPLC-QTOF-MS）测定皮肤表面脂质的成分。采用多元数据分析和富集分析探讨被动和非被动吸烟女性面部 SSL 之间的差异。
在被动和非被动吸烟女性的面部 SSL 中鉴定出 1247 种脂质实体。两组间面部 SSL 的组成存在显著差异。多元数据分析提示后，鉴定出 28 种差异显著的脂质，并将其分为 SSL 颊部的四个类别。在女性额部 SSL 中获得 32 种差异显著的脂质，包括三类脂质。进一步分析显示，与对照组相比，被动吸烟女性的脂肪酸（FA）含量显著降低，甘油脂质（GL）和鞘脂（SP）含量增加。
这些结果表明，被动吸烟女性面部脂质的 GLs 和 SPs 增加，FAs 减少。这些脂质变化可能与氧化应激有关，与烟雾中的物质干扰信号通路有关。被动吸烟影响面部 SSL，并改变皮肤脂质的含量和代谢。
