Chen Tian, Zhao Mengzhen, Mao Zhenxing
Division of Public Health Service and Safety Assessment, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics, Shanghai 200336, China.
Metabolites. 2023 Feb 9;13(2):254. doi: 10.3390/metabo13020254.
Smoking contributes to the formation of skin wrinkles and reduces skin function, but the mechanism is not yet fully proven. This study aims to compare and analyze the effects of smoking on skin lipids and to further investigate the harmful effects of smoking on the skin. A total of 40 subjects (20 male smokers and 20 healthy control males) were recruited for this study. Measurement of hand skin-surface lipids (SSLs) in smoking and healthy control groups was undertaken using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Multivariate data analysis was used to investigate the differences in SSLs between the two groups. There were 1230 lipids detected in the two groups and significant differences in SSLs' composition were observed between them. Under selected conditions, 26 types of lipid with significant differences were observed between the two groups ( < 0.05). Sphingolipids (SP) and glycerolipids (GL) were significantly increased, and sterol lipids (ST) were significantly reduced. Smoking causes changes in skin lipids that disrupt skin homeostasis, making the skin more fragile and more susceptible to skin aging and diseases.
吸烟会导致皮肤皱纹的形成并降低皮肤功能，但其机制尚未得到充分证实。本研究旨在比较和分析吸烟对皮肤脂质的影响，并进一步探究吸烟对皮肤的有害作用。本研究共招募了40名受试者（20名男性吸烟者和20名健康对照男性）。使用超高效液相色谱四极杆飞行时间质谱（UPLC-Q-TOF-MS）对吸烟组和健康对照组的手部皮肤表面脂质（SSL）进行测量。采用多变量数据分析来研究两组之间SSL的差异。两组共检测到1230种脂质，且观察到两组之间SSL的组成存在显著差异。在选定条件下，两组之间观察到26种具有显著差异的脂质（<0.05）。鞘脂（SP）和甘油脂（GL）显著增加，而甾醇脂质（ST）显著减少。吸烟会导致皮肤脂质变化，破坏皮肤稳态，使皮肤更加脆弱，更容易出现皮肤老化和疾病。
