Department of Oral and Maxillofacial Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Republic of Korea.
Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
J Stomatol Oral Maxillofac Surg. 2023 Feb;124(1):101259. doi: 10.1016/j.jormas.2022.08.002. Epub 2022 Aug 5.
Neoveil® is a wound surface-covering agent composed of polyglycolic acid(PGA) effective for secondary healing. This study evaluated the secondary healing property of oral cavity mucosal defects using the PGA sheet. Thirty-four patients who underwent surgical excision of oral benign and malignant lesions, precancerous lesions, and tumors were evaluated. The PGA sheet was placed over the open wound to aid secondary healing. The defects were reviewed post-operatively for secondary healing, contracture, and secondary deformity. Male to female ratio was 20:14, and the mean age was 63.5 years. In all cases, the oral mucosal defect was present after the wide excision of the mucosal lesion. The PGA sheet was used as a surface covering agent which was found to be effective in secondary healing of the wound. Any side effects and adverse reactions which were caused by the PGA sheet was not evident. It can be used to avoid skin graft or free flap reconstruction or deformity from the direct closure in moderate size oral mucosal defect.
Neoveil® 是一种由聚乙醇酸（PGA）组成的创面覆盖剂，对二期愈合有效。本研究采用 PGA 片评估口腔黏膜缺损的二期愈合特性。评估了 34 例因口腔良性和恶性病变、癌前病变和肿瘤而行手术切除的患者。PGA 片覆盖在开放性伤口上，以促进二期愈合。术后对二期愈合、挛缩和继发畸形进行了回顾性检查。男女比例为 20:14，平均年龄为 63.5 岁。在所有病例中，均在广泛切除黏膜病变后出现口腔黏膜缺损。PGA 片作为表面覆盖剂，对创面的二期愈合有效。PGA 片未引起任何副作用和不良反应。在中等大小的口腔黏膜缺损中，它可用于避免皮片移植或游离皮瓣重建或直接闭合引起的畸形。
