Park Young-Kyoung, Ledesma-Amaro Rodrigo
Imperial College Centre for Synthetic Biology, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK.
Imperial College Centre for Synthetic Biology, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK.
Trends Biotechnol. 2023 Feb;41(2):242-254. doi: 10.1016/j.tibtech.2022.07.006. Epub 2022 Aug 6.
Yarrowia lipolytica possesses natural and engineered traits that make it a good host for the industrial bioproduction of chemicals, fuels, foods, and pharmaceuticals. In recent years, academic and industrial researchers have assessed its potential, developed synthetic biology techniques, improved its features, scaled its processes, and identified its limitations. Both publications and patents related to Y. lipolytica have shown a drastic increase during the past decade. Here, we discuss the characteristics of this yeast that make it suitable for industry and the remaining challenges for its wider use at large scale. We present evidence herein that shows the importance and potential of Y. lipolytica in bioproduction such that it may soon be one of the preferred choices of industry.
解脂耶氏酵母具有天然和工程化的特性，使其成为工业生物生产化学品、燃料、食品和药品的良好宿主。近年来，学术和工业研究人员评估了它的潜力，开发了合成生物学技术，改进了它的特性，扩大了其生产工艺规模，并确定了其局限性。在过去十年中，与解脂耶氏酵母相关的出版物和专利都有了急剧增加。在此，我们讨论了这种酵母适合工业生产的特性以及其大规模更广泛应用所面临的挑战。我们在此提供的证据表明了解脂耶氏酵母在生物生产中的重要性和潜力，因此它可能很快成为工业的首选之一。
