Cross F W, Bowker T J, Bown S G
Br J Surg. 1987 May;74(5):430-5. doi: 10.1002/bjs.1800740539.
The application of laser energy to percutaneous recanalization of diseased blood vessels is of interest to vascular surgeons and radiologists. We have examined the effect of pulsed infrared light from a 100 microseconds pulsed Nd-YAG laser on the dog aorta in order to determine the dose response, perforation thresholds and healing properties in vascular tissue. We used 100 microseconds pulses of 0.5 J energy at 10 Hz repetition rate via a 400 micron optical fibre to make 205 craters in 10 dogs at total energies of 5-25 J. The perforation threshold was 15 J in six animals and 20 J in four. The dose response was linear at 10 micron tissue vaporized per Joule delivered. Animals were killed immediately and at intervals of 24 h, 4, 7 and 10 days, 2, 3 and 6 weeks, and 3 and 6 months. Material was retrieved for histology and examined by light and scanning electron microscopy. The tissue exhibited features of laser damage that were less marked than those seen with continuous wave lasers; there was less heat damage surrounding the craters which healed well, even after perforation. This laser is likely to be suitable for human laser angioplasty provided the energy is given in increments of 15 J or less.
将激光能量应用于经皮血管再通术，这引起了血管外科医生和放射科医生的兴趣。我们研究了100微秒脉冲钕钇铝石榴石激光发出的脉冲红外光对犬主动脉的影响，以确定血管组织中的剂量反应、穿孔阈值和愈合特性。我们通过一根400微米的光纤，以10赫兹的重复频率使用能量为0.5焦耳的100微秒脉冲，在10只犬身上制造了205个弹坑，总能量为5 - 25焦耳。6只动物的穿孔阈值为15焦耳，4只动物为20焦耳。每传递1焦耳能量，在组织汽化10微米时剂量反应呈线性。动物分别在即刻、24小时、4天、7天、10天、2周、3周、6周、3个月和6个月时被处死。取出材料进行组织学检查，并通过光学显微镜和扫描电子显微镜观察。该组织表现出的激光损伤特征不如连续波激光造成的损伤明显；弹坑周围的热损伤较小，即使穿孔后也愈合良好。如果以15焦耳或更低的增量给予能量，这种激光可能适用于人体激光血管成形术。
