Abela G S, Crea F, Seeger J M, Franzini D, Fenech A, Normann S J, Feldman R L, Pepine C J, Conti C R
Am J Cardiol. 1985 Dec 1;56(15):983-8. doi: 10.1016/0002-9149(85)90417-5.
To evaluate the healing response of both normal and atherosclerotic arteries to laser radiation, 7 mongrel dogs and 4 hypercholesterolemic atherosclerotic monkeys underwent catheterization with a right Judkins catheter-optical fiber system designed to maximize arterial wall injury. Argon laser radiation was then delivered to the abdominal aorta and iliofemoral arteries. In the 11 animals, a total of 917 sites were irradiated in 33 arteries. Angiography did not reveal dissection or aneurysm formation; occlusive thrombosis was found in 2 arteries. Perforation of the arterial wall was a frequent complication. In animals killed between 1 hour and 4 days, light and electron microscopy of lased sites showed craters filled with a coagulum of blood and cellular debris with only a few adherent platelets. Healing occurred with a minimal inflammatory response and involved both fibroblasts and smooth muscle cells. Reendothelialization was seen in all animals killed between 7 and 14 days after lasing and was complete by 30 to 60 days. Within this period, no accelerated atherosclerosis was seen at lased sites in the hypercholesterolemic monkeys. It is concluded that transluminal lasing of normal arteries in dogs and in atherosclerotic arteries of monkeys is followed by healing and reendothelialization within a few weeks.
为评估正常动脉和动脉粥样硬化动脉对激光辐射的愈合反应，7只杂种犬和4只高胆固醇血症动脉粥样硬化猴接受了使用旨在使动脉壁损伤最大化的右Judkins导管 - 光纤系统进行的导管插入术。然后将氩激光辐射传递至腹主动脉和髂股动脉。在这11只动物中，33条动脉的总共917个部位接受了照射。血管造影未显示夹层或动脉瘤形成；在2条动脉中发现了闭塞性血栓形成。动脉壁穿孔是常见的并发症。在1小时至4天内处死的动物中，激光照射部位的光镜和电镜检查显示坑洞中充满血液凝块和细胞碎片，仅有少量黏附的血小板。愈合过程伴有轻微的炎症反应，涉及成纤维细胞和平滑肌细胞。在激光照射后7至14天处死的所有动物中均可见到再内皮化，至30至60天时完成。在此期间，高胆固醇血症猴的激光照射部位未出现动脉粥样硬化加速进展的情况。结论是，犬的正常动脉和猴的动脉粥样硬化动脉经腔内激光照射后，在几周内会发生愈合和再内皮化。
