Liu Weiqi, Zhang Qingui, Liu Weiling, Qiu Cuiqing
Department of Clinical Laboratory, The Maternal and Children Health Care Hospital (Huzhong Hospital) of Huadu, Guangzhou, Guangdong, 510800, People's Republic of China.
Department of Clinical Laboratory, Foshan Fosun Chancheng Hospital, Foshan, Guangdong, 528000, People's Republic of China.
Environ Sci Pollut Res Int. 2023 Jan;30(2):2891-2903. doi: 10.1007/s11356-022-22379-0. Epub 2022 Aug 8.
The global prevalence of gestational diabetes mellitus (GDM) is increasing annually, and previous research reports on the relationship between exposure to air pollutants and GDM are not completely consistent. We investigated the association between air pollutant exposure and GDM in pregnant women in a retrospective cohort study in Guangzhou. We found that in the first trimester, exposure to PM and CO showed a significant association with GDM. In the second trimester, exposure to PM was significantly associated with GDM. In the third trimester, exposure to PM, PM, NO, SO, and CO at IQR4 (odds ratio [OR] = 1.271, 95% confidence interval [CI]: 1.179-1.370; OR = 1.283, 95% CI: 1.191-1.383; OR = 1.230, 95% CI: 1.145-1.322; OR = 1.408, 95% CI: 1.303-1.522; OR = 1.150, 95% CI: 1.067-1.240, respectively) compared with IQR1 was positively associated with GDM. However, exposure to NO was negatively associated with GDM in the first and second trimesters, and O was negatively associated with GDM in the second and third trimesters. We found that the correlation between air pollutants and GDM in different trimesters of pregnancy was not completely consistent in this retrospective cohort study. During pregnancy, there may be an interaction between air pollutant exposure and other factors, such as pregnant women's age, occupation, anemia status, pregnancy-induced hypertension status, and pregnancy season.
全球妊娠期糖尿病（GDM）的患病率逐年上升，先前关于接触空气污染物与GDM之间关系的研究报告并不完全一致。我们在广州进行了一项回顾性队列研究，调查了孕妇接触空气污染物与GDM之间的关联。我们发现，在孕早期，接触细颗粒物（PM）和一氧化碳（CO）与GDM存在显著关联。在孕中期，接触PM与GDM显著相关。在孕晚期，与四分位距1（IQR1）相比，接触IQR4的PM、PM、氮氧化物（NO）、二氧化硫（SO）和CO（优势比[OR]分别为1.271，95%置信区间[CI]：1.179 - 1.370；OR = 1.283，95% CI：1.191 - 1.383；OR = 1.230，95% CI：1.145 - 1.322；OR = 1.408，95% CI：1.303 - 1.522；OR = 1.150，95% CI：1.067 - 1.240）与GDM呈正相关。然而，在孕早期和孕中期，接触NO与GDM呈负相关，在孕中期和孕晚期，接触臭氧（O）与GDM呈负相关。我们发现在这项回顾性队列研究中，不同孕期空气污染物与GDM之间的相关性并不完全一致。在孕期，接触空气污染物与其他因素之间可能存在相互作用，如孕妇年龄、职业、贫血状况、妊娠期高血压状况和妊娠季节。
